Journal article
A PEG‐Based Oligomer as a Backbone Replacement for Surface‐Exposed Loops in a Protein Tertiary Structure
Chembiochem : a European journal of chemical biology, Vol.13(8), pp.1107-1111
05/29/2012
DOI: 10.1002/cbic.201200200
PMID: 22539233
Abstract
PEGged out: Poly(ethylene glycol), a simple biocompatible polymer, can replace natural loop segments in a 56‐residue protein domain with a well‐defined tertiary structure. Biophysical characterization of chimeras of the protein GB1 coupled with molecular dynamics simulations show that PEG enhances local backbone torsional freedom without compromising the overall protein fold or function.
Details
- Title: Subtitle
- A PEG‐Based Oligomer as a Backbone Replacement for Surface‐Exposed Loops in a Protein Tertiary Structure
- Creators
- Zachary E ReinertEli D MusselmanAdrian H ElcockW. Seth Horne
- Resource Type
- Journal article
- Publication Details
- Chembiochem : a European journal of chemical biology, Vol.13(8), pp.1107-1111
- Publisher
- WILEY‐VCH Verlag; Weinheim
- DOI
- 10.1002/cbic.201200200
- PMID
- 22539233
- ISSN
- 1439-4227
- eISSN
- 1439-7633
- Number of pages
- 5
- Grant note
- University of Pittsburgh NSF (0448029)
- Language
- English
- Date published
- 05/29/2012
- Academic Unit
- Physics and Astronomy; Biochemistry and Molecular Biology
- Record Identifier
- 9984024549802771
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