A Phase 1 Double-Blinded Trial to Evaluate Safety, Immunogenicity, and Dosing of Measles-Vectored Chikungunya Virus Vaccine (MV-CHIK) in Healthy Adults

Patricia Winokur; Theresa E Hegmann; Hana M El Sahly; Evan J Anderson; DMID 15-0038 Study Group

doi:10.1093/infdis/jiaf571

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A Phase 1 Double-Blinded Trial to Evaluate Safety, Immunogenicity, and Dosing of Measles-Vectored Chikungunya Virus Vaccine (MV-CHIK) in Healthy Adults

Journal article

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A Phase 1 Double-Blinded Trial to Evaluate Safety, Immunogenicity, and Dosing of Measles-Vectored Chikungunya Virus Vaccine (MV-CHIK) in Healthy Adults

Patricia Winokur, Theresa E Hegmann, Hana M El Sahly, Evan J Anderson and DMID 15-0038 Study Group

The Journal of infectious diseases, Vol.233(3), pp.e641-e645

03/15/2026

DOI: 10.1093/infdis/jiaf571

PMCID: PMC13017142

PMID: 41313671

Appears in UI Libraries Support Open Access

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Abstract

This study of a measles-vectored vaccine for chikungunya virus (MV-CHIK) was a Phase 1 randomized, double-blinded, placebo-controlled trial with varying intervals between the 2 doses. The 6 cohorts each had 30 subjects, of which 25 received MV-CHIK and 5 received placebo. The 5 × 105 TCID50 dose was superior to the 5 × 104 TCID50 dose, and longer dosing intervals resulted in higher titers in the high dose groups. Mild to moderate injection site and systemic reactogenicity was common but brief. There was no evidence of prolonged vaccine-related arthralgia.

vaccine

measles-vectored vaccine

chikungunya

phase 1 trial

UIOWA OA Agreement

Details

Title: Subtitle: A Phase 1 Double-Blinded Trial to Evaluate Safety, Immunogenicity, and Dosing of Measles-Vectored Chikungunya Virus Vaccine (MV-CHIK) in Healthy Adults
Creators: Patricia Winokur - University of Iowa, Department of Internal Medicine, Iowa City, Iowa, USA
Theresa E Hegmann - University of Iowa, Department of Physician Assistant Studies, Iowa City, Iowa, USA
Hana M El Sahly - Baylor College of Medicine
Evan J Anderson - Emory University
DMID 15-0038 Study Group
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.233(3), pp.e641-e645
DOI: 10.1093/infdis/jiaf571
PMID: 41313671
PMCID: PMC13017142
NLM abbreviation: J Infect Dis
ISSN: 1537-6613
eISSN: 1537-6613
Publisher: Oxford University Press
Grant note: Emory University National Institute of Allergy and Infectious Diseases HHSN272201300015I / NIAID NIH HHS NIH HHS HHSN272201300018I / NIAID NIH HHS HHSN272201300020I / NIAID NIH HHS
Language: English
Electronic publication date: 11/28/2025
Date published: 03/15/2026
Academic Unit: Physician Assistant Studies; Infectious Diseases; Medicine Administration; Internal Medicine
Record Identifier: 9985035042902771

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