Journal article
A Phase I Study of Cisplatinum plus 5-Fluorouracil in Modulation with Citrovorum Factor in Metastatic Colorectal Carcinoma
Journal of chemotherapy (Florence), Vol.3(3), pp.170-175
06/01/1991
DOI: 10.1080/1120009X.1991.11739087
PMID: 1919654
Abstract
A phase I study of 5-fluorouracil 600 mg/m
2
/week and folinic acid 500 mg/m
2
/week on day 1 and cisplatin administered weekly on day 2 was carried out on 30 patients with metastatic colorectal carcinoma of which 20 patients were pretreated with 5-fluorouracil. The first group of patients received cisplatin at the dose of 5 mg/m
2
/week. Cisplatin was then escalated to 10, 15, 20, 25, 30, and 35 mg/m
2
/week for subsequent groups of patients. Gastrointestinal side-effects were the dose -limiting toxicity. A therapy related death was seen at the dose of 35 mg/m
2
/week of cisplatin. The maximally tolerated dose of cisplatin in combination with 5-fluorouracil and citrovorum factor is 20 mg/m
2
/week. The optimally tolerated dose of 5-fluorouracil is 400 mg/m
2
/week in modulation with citrovorum factor 500 mg/m
2
/week. The recommended doses for a phase II study are cisplatin 20 mg/m
2
/week, 5-fluorouracil 400 mg/m
2
/week, and citrovorum factor 500 mg/m
2
/week.
Details
- Title: Subtitle
- A Phase I Study of Cisplatinum plus 5-Fluorouracil in Modulation with Citrovorum Factor in Metastatic Colorectal Carcinoma
- Creators
- S. Palmeri - University of PalermoV. Gebbia - Section of Clinical Oncology, Institute of Pharmacology, University of PalermoA. Russo - Section of Clinical Oncology, Institute of Pharmacology, University of PalermoN. Gebbia - Section of Clinical Oncology, Institute of Pharmacology, University of PalermoY. Rustum - Department of Experimental TherapeuticsL. Rausa - Section of Clinical Oncology, Institute of Pharmacology, University of PalermoP. Creaven - Clinical Pharmacology and TherapeuticsN. Petrelli - Surgical Oncology Roswell Park Memorial Institute
- Resource Type
- Journal article
- Publication Details
- Journal of chemotherapy (Florence), Vol.3(3), pp.170-175
- Publisher
- Taylor & Francis
- DOI
- 10.1080/1120009X.1991.11739087
- PMID
- 1919654
- ISSN
- 1120-009X
- eISSN
- 1973-9478
- Language
- English
- Date published
- 06/01/1991
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359900102771
Metrics
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