A Pilot Study to Evaluate the Effects of Topically Applied Cosmetic Creams on Epidermal Responses

Megan N Kelchen; Gopi Menon; Patrick Ten Eyck; Donald Prettypaul; Nicole K Brogden

doi:10.1159/000490531

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A Pilot Study to Evaluate the Effects of Topically Applied Cosmetic Creams on Epidermal Responses

Journal article

Open access

Peer reviewed

A Pilot Study to Evaluate the Effects of Topically Applied Cosmetic Creams on Epidermal Responses

Megan N Kelchen, Gopi Menon, Patrick Ten Eyck, Donald Prettypaul and Nicole K Brogden

Skin pharmacology and physiology, Vol.31(5), pp.269-282

2018

DOI: 10.1159/000490531

PMCID: PMC6112171

PMID: 30110695

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https://doi.org/10.1159/000490531View

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Abstract

Application of exogenous products, such as creams, to the skin can result in subclinical changes in selected epidermal functions such as transepidermal water loss (TEWL), hydration, redness, and pH; these changes may lead to or contribute to irritation. Changes in skin surface inflammatory factors may provide further insight into this potential for irritation. The objective of this study was to evaluate the changes in epidermal properties and inflammatory mediators after 4 days of topical application of 2 different polymers formulated in cosmetic creams. Ten healthy volunteers (mean age ± SD: 20.0 ± 2.4 years) completed the study. TEWL, color, and pH were not significantly different after repeated application of these polymers. Hydration was significantly lower at sites treated with polymer A after 5 days. Significant increases in IL-1α, IL-1RA, and IL-1β were observed after cream application at sites treated with polymer A. This is the first study to apply noninvasive measurements to quantify subclinical changes in epidermal properties and inflammatory mediator expression before and after the application of a cosmetic product, which will allow for a more enhanced safety profile to be achieved.

Adolescent

Adult

Cosmetics - pharmacology

Cytokines - metabolism

Epidermis - chemistry

Epidermis - drug effects

Epidermis - metabolism

Erythema - chemically induced

Female

Humans

Hydrogen-Ion Concentration

Male

Pilot Projects

Polymers - pharmacology

Skin Cream - pharmacology

Water - metabolism

Young Adult

Details

Title: Subtitle: A Pilot Study to Evaluate the Effects of Topically Applied Cosmetic Creams on Epidermal Responses
Creators: Megan N Kelchen - University of Iowa
Gopi Menon - Ashland (United States)
Patrick Ten Eyck - University of Iowa
Donald Prettypaul - Ashland (United States)
Nicole K Brogden - University of Iowa
Resource Type: Journal article
Publication Details: Skin pharmacology and physiology, Vol.31(5), pp.269-282
DOI: 10.1159/000490531
PMID: 30110695
PMCID: PMC6112171
NLM abbreviation: Skin Pharmacol Physiol
ISSN: 1660-5527
eISSN: 1660-5535
Grant note: U54 TR001356 / NCATS NIH HHS
Language: English
Date published: 2018
Academic Unit: Dermatology; Pharmaceutical Sciences and Experimental Therapeutics; Biostatistics
Record Identifier: 9984296305802771

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