Journal article
A Pooled Analysis of Bladder Cancer Case–Control Studies Evaluating Smoking in Men and Women
Cancer causes & control, Vol.17(1), pp.71-79
02/2006
DOI: 10.1007/s10552-005-0389-0
PMID: 16411055
Abstract
Objective A recent study suggested that risk of bladder cancer may be higher in women than in men who smoked comparable amounts of cigarettes. We pooled primary data from 14 case–control studies of bladder cancer from Europe and North America and evaluated differences in risk of smoking by gender.Methods The pooled analysis included 8316 cases (21% women) and 17,406 controls (28% women) aged 30–79 years. Odds ratios (ORs) and 95% confidence intervals (95% CI) for smoking were adjusted for age and study. Exposure-response was evaluated in a stratified analysis by gender and by generalized additive models.Results The odds ratios for current smokers compared to nonsmokers were 3.9 (95% CI 3.5–4.3) for males and 3.6 (3.1–4.1) for females. In 11 out of 14 studies, ORs were slightly higher in men. ORs for current smoking were similar for men (OR = 3.4) and women (OR = 3.7) in North America, while in Europe men (OR = 5.3) had higher ORs than women (OR = 3.9). ORs increased with duration and intensity in both genders and the exposure-response patterns were remarkably similar between genders.Conclusion These results do not support the hypothesis that women have a higher relative risk of smoking-related bladder cancer than men.
Details
- Title: Subtitle
- A Pooled Analysis of Bladder Cancer Case–Control Studies Evaluating Smoking in Men and Women
- Creators
- Diana Puente - Respiratory and Environmental Health Research Unit Municipal Institute of Medical Research (IMIM) 80 Dr Aiguader Rd. Barcelona 08003 SpainPatricia Hartge - Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda USAEberhard Greiser - Bremen Institute for Prevention Research and Social Medicine Bremen GermanyKenneth Cantor - Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda USAWill King - Department of Community Health and Epidemiology Queen’s University Ontario CanadaCarlos González - Department of Epidemiology Catalan Institute of Oncology Barcelona SpainSylvaine Cordier - INSERM U435 Université de Rennes I FrancePaolo Vineis - Unit of Cancer Epidemiology University of Turin ItalyElsebeth Lynge - Institute of Public Health University of Copenhagen DenmarkJenny Chang-Claude - German Cancer Research CenterStefano Porru - Institute of Occupational Health University of Brescia ItalyAnastasia Tzonou - Department of Hygiene and Epidemiology Medical School of Athens Athens GreeceKarl-Heinz Jöckel - Institut für Medizinische Informatik Biometrie und Epidemiologie Essen GermanyConsol Serra - Corporació Parc Taulí, Sabadell Spain and Pompeu Fabra University Barcelona SpainMartine Hours - Institut d’Épidémiologie Université Claude Bernard Lyon FranceCharles Lynch - University of Iowa, EpidemiologyUlrich Ranft - Institut für Umweltmedizinische Forschung (IUF), Heinrich-Heine-Universität Düsseldorf GermanyJürgen Wahrendorf - Deutsches Krebsforschungszentrum Abteilung Epidemiologie Heidelberg GermanyDebra Silverman - Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda USAFrancisco Fernandez - Respiratory and Environmental Health Research Unit Municipal Institute of Medical Research (IMIM) 80 Dr Aiguader Rd. Barcelona 08003 SpainPaolo Boffetta - International Agency for Research on Cancer Lyon FranceManolis Kogevinas - Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda USA
- Resource Type
- Journal article
- Publication Details
- Cancer causes & control, Vol.17(1), pp.71-79
- Publisher
- Kluwer Academic Publishers
- DOI
- 10.1007/s10552-005-0389-0
- PMID
- 16411055
- ISSN
- 0957-5243
- eISSN
- 1573-7225
- Language
- English
- Date published
- 02/2006
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995025502771
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