Journal article
A Potential Preclinical Migraine Model: CGRP-Sensitized Mice
Molecular and cellular pharmacology (Windsor Mill, Md.), Vol.1(5), pp.264-270
2009
DOI: 10.4255/mcpharmacol.09.32
PMID: 20336186
Abstract
The neuropeptide calcitonin gene-related peptide (CGRP) plays a key role in migraine. However, a major challenge for studying CGRP actions is the lack of animal models for migraine. Clinical studies suggested that migraineurs are more sensitive to CGRP than people who do not suffer from migraine. We therefore generated a transgenic mouse that is sensitized to CGRP (nestin/hRAMP1 mice). The mice have elevated expression of a subunit of the CGRP receptor, human receptor activity-modifying protein 1 (hRAMP1). Nestin/hRAMP1 mice have two symptoms of migraine: photophobia and mechanical allodynia. The light aversion was greatly enhanced by intracerebroventricular administration of CGRP. CGRP had little effect on motility in the light zone, but once in the dark, the mice moved less than controls. The CGRP-induced light aversion was attenuated by co-administration of the CGRP receptor antagonist olcegepant. These findings suggest that CGRP acts as a neuromodulator to increase sensory responses and that regulation of a single gene,
hRAMP1
, could potentially contribute to migraine susceptibility.
Details
- Title: Subtitle
- A Potential Preclinical Migraine Model: CGRP-Sensitized Mice
- Creators
- Andrew F Russo - Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IowaAdisa Kuburas - Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IowaEric A Kaiser - Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IowaAnn C Raddant - Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IowaAna Recober - Department of Neurology, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Molecular and cellular pharmacology (Windsor Mill, Md.), Vol.1(5), pp.264-270
- DOI
- 10.4255/mcpharmacol.09.32
- PMID
- 20336186
- NLM abbreviation
- Mol Cell Pharmacol
- ISSN
- 1938-1247
- eISSN
- 1938-1247
- Language
- English
- Date published
- 2009
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center
- Record Identifier
- 9984020854502771
Metrics
35 Record Views