Journal article
A Prospective Randomized Trial to Assess Oral Versus Intravenous Antibiotics for the Treatment of Postoperative Wound Infection After Extremity Fractures (POvIV Study)
Journal of orthopaedic trauma, Vol.31 Suppl 1(1), pp.S32-S38
04/2017
DOI: 10.1097/BOT.0000000000000802
PMID: 28323799
Abstract
Patients surgically treated for infection after extremity fractures are typically discharged with a 6- to 12-week antibiotic regimen. Intravenous (IV) antibiotics are associated with significant cost and potential complications of deep vein thrombosis, line clotting, and sepsis. Many of the pathogens that cause musculoskeletal infection have both oral (PO) and IV antibiotic options with adequate bioavailability and antibacterial effect, yet IV antibiotics remain the standard of care absent evidence that PO options are clinically as efficacious. The POvIV study is a prospective, multicenter, randomized trial to compare PO with IV antibiotic therapy in patients with postoperative wound infections after extremity fractures. Patients between the ages of 18 and 84 who have a culture-positive surgical site infection after internal fixation for fracture repair or arthrodesis are approached for this study, and if they provide consent, are randomly assigned to receive either PO or IV antibiotics. Antibiotic selection is based on culture and sensitivity results. Randomization determines the route of administration. Patients are followed for 1 year after study enrollment. This study will be the largest prospective randomized trial to evaluate the safety and effectiveness of PO antibiotic use for treatment of postoperative wound infections. Results will inform clinician decisions on antibiotic delivery in patients with postoperative wound infections.
Details
- Title: Subtitle
- A Prospective Randomized Trial to Assess Oral Versus Intravenous Antibiotics for the Treatment of Postoperative Wound Infection After Extremity Fractures (POvIV Study)
- Creators
- William T Obremskey - Vanderbilt UniversityAndrew H SchmidtRobert V OʼTooleJennifer DeSantoSaam MorshedPaul Tornetta IIIClinton K MurrayClifford B JonesDaniel O ScharfsteinTara J TaylorAnthony R CarliniRenan C CastilloMajor Extremity Trauma Research Consortium (METRC)
- Contributors
- Michael C Willey (Contributor) - University of Iowa, Orthopedics and Rehabilitation
- Resource Type
- Journal article
- Publication Details
- Journal of orthopaedic trauma, Vol.31 Suppl 1(1), pp.S32-S38
- DOI
- 10.1097/BOT.0000000000000802
- PMID
- 28323799
- NLM abbreviation
- J Orthop Trauma
- ISSN
- 0890-5339
- eISSN
- 1531-2291
- Grant note
- T32 HS000029 / AHRQ HHS
- Language
- English
- Date published
- 04/2017
- Academic Unit
- Orthopedics and Rehabilitation; Injury Prevention Research Center
- Record Identifier
- 9984083278202771
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