Journal article
A Prospective Study Evaluating the Effects of SSRI Exposure on Cardiac Size and Function in Newborns
Neonatology (Basel, Switzerland), Vol.115(4), pp.320-327
2019
DOI: 10.1159/000496451
PMCID: PMC7009783
PMID: 30836356
Abstract
Selective serotonin reuptake inhibitors (SSRIs) are antidepressants prescribed in 10% of pregnancies in the USA. We have previously shown in preclinical studies that sertraline exposure impacts cardiomyocyte development, leading to reductions in left ventricular size and cardiac function.
We hypothesized that in utero SSRI exposure will lead to reduced left ventricular dimensions and cardiac function on echocardiography immediately after birth.
Twenty term infants with and 21 term infants without in utero exposure to SSRIs underwent echocardiograms to assess cardiac size and function. The exclusion criteria for infants were prematurity, small or large for gestational age, any respiratory or cardiovascular support needed after birth, and any major congenital malformation.
Infants exposed to in utero SSRIs had significantly reduced right ventricular dimensions in the diastole (controls 1.0 cm [0.86, 1.20], SSRI 0.89 cm [0.730, 1.05], p = 0.03), and left ventricular lengths in the diastole and systole (diastole: controls 3.4 cm [3.25, 3.65], SSRI 3.25 cm [3.10, 3.45], p = 0.03; systole: controls 2.9 cm [2.65, 3.05], SSRI 2.6 cm [2.50, 2.85], p = 0.01). No differences were observed in cardiac function. Importantly, there were no differences in maternal conditions or infant birth weight, body surface area, or gestational age.
Our findings suggest an association between in utero exposure to SSRIs and ventricular size in infants. Given the increasing use of SSRIs during pregnancy and the importance of early life programming on future cardiovascular health, larger studies need to be completed to determine if in utero SSRI exposure impacts ventricular size.
Details
- Title: Subtitle
- A Prospective Study Evaluating the Effects of SSRI Exposure on Cardiac Size and Function in Newborns
- Creators
- Deidra A Ansah - Department of Pediatrics, University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, USA.Benjamin E Reinking - Department of Pediatrics, University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, USA.Tarah T Colaizy - Department of Pediatrics, University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, USA.Robert D Roghair - Department of Pediatrics, University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, USA.Sarah E Haskell - Department of Pediatrics, University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, USA.
- Resource Type
- Journal article
- Publication Details
- Neonatology (Basel, Switzerland), Vol.115(4), pp.320-327
- DOI
- 10.1159/000496451
- PMID
- 30836356
- PMCID
- PMC7009783
- ISSN
- 1661-7800
- eISSN
- 1661-7819
- Grant note
- T35 HL007485 / NHLBI NIH HHS T32 HL007413 / NHLBI NIH HHS K12 HD027748 / NICHD NIH HHS
- Language
- English
- Date published
- 2019
- Academic Unit
- Critical Care; Cardiology; Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984354157002771
Metrics
34 Record Views