Journal article
A Quantitative Study of λ-Phage SWITCH and Its Components
Biophysical Journal, Vol.92(8), pp.2685-2693
04/15/2007
DOI: 10.1529/biophysj.106.097089
PMCID: PMC1831702
PMID: 17259278
Abstract
We propose what we believe is a new model to quantitatively describe the
λ
-phage SWITCH system. The model incorporates facilitated transfer mechanism of transcription factor, which can be simplified into a two-step reaction. We first sequentially obtain two indispensable parameters by fitting our model to experimental data of two simple systems, and then apply them to study the natural
λ
-SWITCH system. By incorporating the facilitated transfer mechanism, we find that in RecA
−
host
Escherichia coli
, the wild-type
λ-
lysogenic state is in a monostable regime rather than in a bistable regime. Furthermore, the model explains the weak role of Cro protein and probably sheds light on the evolution of
λ
-Cro protein, which is known to be structurally distinct from the other Cros in lambdoid family members.
Details
- Title: Subtitle
- A Quantitative Study of λ-Phage SWITCH and Its Components
- Creators
- Chunbo Lou - Center for Theoretical Biology and School of Physics, Peking University, Beijing, 100871, ChinaXiaojing Yang - Center for Theoretical Biology and School of Physics, Peking University, Beijing, 100871, ChinaXili Liu - Center for Theoretical Biology and School of Physics, Peking University, Beijing, 100871, ChinaBin He - Center for Theoretical Biology and School of Physics, Peking University, Beijing, 100871, ChinaQi Ouyang - Center for Theoretical Biology and School of Physics, Peking University, Beijing, 100871, China
- Resource Type
- Journal article
- Publication Details
- Biophysical Journal, Vol.92(8), pp.2685-2693
- Publisher
- The Biophysical Society
- DOI
- 10.1529/biophysj.106.097089
- PMID
- 17259278
- PMCID
- PMC1831702
- ISSN
- 0006-3495
- eISSN
- 1542-0086
- Language
- English
- Date published
- 04/15/2007
- Academic Unit
- Biology
- Record Identifier
- 9983992063302771
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