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A Randomized, Controlled Trial of Corticosteroids in the Treatment of Acute Optic Neuritis
Journal article   Peer reviewed

A Randomized, Controlled Trial of Corticosteroids in the Treatment of Acute Optic Neuritis

Roy W Beck, Patricia A Cleary, Malcolm M Anderson, John L Keltner, William T Shults, David I Kaufman, Edward G Buckley, James J Corbett, Mark J Kupersmith, Neil R Miller, …
The New England Journal of Medicine, Vol.326(9), pp.581-588
02/27/1992
DOI: 10.1056/NEJM199202273260901
PMID: 1734247

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Abstract

OPTIC NEURITIS is an acute demyelinating disease of the optic nerve. It may occur in a patient with confirmed multiple sclerosis or as an isolated neurologic finding, in which case it may represent a forme fruste of multiple sclerosis. 1 The typical clinical profile consists of sudden loss of vision, which can vary in severity from a slight deficit in the field of vision to complete loss of light perception, followed by spontaneous improvement over several months. Most patients have lasting symptoms of visual impairment, and even when visual acuity returns to normal, abnormalities are common in other aspects of visual . . .

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