Journal article
A Randomized Controlled Trial of a Paclitaxel-Eluting Stent Versus a Similar Bare-Metal Stent in Saphenous Vein Graft Lesions The SOS (Stenting Of Saphenous Vein Grafts) Trial
Journal of the American College of Cardiology, Vol.53(11), pp.919-928
03/17/2009
DOI: 10.1016/j.jacc.2008.11.029
PMID: 19281920
Abstract
Objectives The aim of this study was to compare the frequency of angiographic restenosis and clinical events between a paclitaxel-eluting stent (PES) and a similar bare-metal stent (BMS) in saphenous vein graft (SVG) lesions.
Background There are conflicting and mostly retrospective data on outcomes after drug-eluting stent implantation in SVGs.
Methods Patients requiring SVG lesion stenting were randomized to BMS or PES. The primary study end point was binary in-segment restenosis at 12-month follow-up quantitative coronary angiography. Secondary end points included death, myocardial infarction, ischemia-driven target vessel and lesion revascularization, and target vessel failure.
Results Eighty patients with 112 lesions in 88 SVGs were randomized to a BMS (39 patients, 43 grafts, 55 lesions) or PES (41 patients, 45 grafts, 57 lesions). Binary angiographic restenosis occurred in 51% of the BMS-treated lesions versus 9% of the PES-treated lesions (relative risk: 0.18; 95% confidence interval [CI]: 0.07 to 0.48, p < 0.0001). During a median follow-up of 1.5 years the PES patients had less target lesion revascularization (28% vs. 5%, hazard ratio: 0.38; 95% CI: 0.15 to 0.74, p = 0.003) and target vessel failure (46% vs. 22%, hazard ratio: 0.65; 95% CI: 0.42 to 0.96, p = 0.03), a trend toward less target vessel revascularization (31% vs. 15%, hazard ratio: 0.66; 95% CI: 0.39 to 1.05, p = 0.08) and myocardial infarction (31% vs. 15%, hazard ratio: 0.67; 95% CI: 0.40 to 1.08, p = 0.10), and similar mortality (5% vs. 12%, hazard ratio: 1.56; 95% CI: 0.72 to 4.11, p = 0.27).
Conclusions In SVG lesions, PES are associated with lower rates of angiographic restenosis and target vessel failure than BMS. (The SOS [Stenting of Saphenous Vein Grafts] Randomized-Controlled Trial; NCT00247208) (J Am Coll Cardiol 2009; 53: 919-28) (C) 2009 by the American College of Cardiology Foundation
Details
- Title: Subtitle
- A Randomized Controlled Trial of a Paclitaxel-Eluting Stent Versus a Similar Bare-Metal Stent in Saphenous Vein Graft Lesions The SOS (Stenting Of Saphenous Vein Grafts) Trial
- Creators
- Emmanouil S. Brilakis - Internal MedicineChristopher Lichtenwalter - Raytheon TechnologiesJames A. de Lemos - Internal MedicineMichele Roesle - Raytheon TechnologiesOwen Obel - Internal MedicineDonald Haagen - Raytheon TechnologiesBilal Saeed - University of ToledoChiranjeevi Gadiparthi - Raytheon TechnologiesJoseph K. Bissett - Cent Arkansas Vet Hlthcare Syst, Little Rock, AR USARajesh Sachdeva - VA Medical CenterVassilios V. Voudris - Onassis Cardiac Surgery CenterPanagiotis Karyofillis - Onassis Cardiac Surgery CenterBiswajit Kar - VA Medical CenterJames Rossen - VA Medical CenterPanayotis Fasseas - Marianjoy Rehabilitation HospitalPeter Berger - Geisinger Medical CenterSubhash Banerjee - Internal Medicine
- Resource Type
- Journal article
- Publication Details
- Journal of the American College of Cardiology, Vol.53(11), pp.919-928
- Publisher
- Elsevier
- DOI
- 10.1016/j.jacc.2008.11.029
- PMID
- 19281920
- ISSN
- 0735-1097
- eISSN
- 1558-3597
- Number of pages
- 10
- Language
- English
- Date published
- 03/17/2009
- Academic Unit
- Neurology; Cardiovascular Medicine; Neurosurgery; Internal Medicine
- Record Identifier
- 9984303013202771
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