A Randomized Controlled Trial of the Use of Oral Glucose with or without Gentle Facilitated Tucking of Infants during Neonatal Echocardiography

Pascal M Lavoie; Amelie Stritzke; Joseph Ting; Mohammad Jabr; Amish Jain; Eddie Kwan; Ela Chakkarapani; Paul Brooks; Rollin Brant; Patrick J McNamara; Liisa Holsti

doi:10.1371/journal.pone.0141015

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A Randomized Controlled Trial of the Use of Oral Glucose with or without Gentle Facilitated Tucking of Infants during Neonatal Echocardiography

Journal article

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A Randomized Controlled Trial of the Use of Oral Glucose with or without Gentle Facilitated Tucking of Infants during Neonatal Echocardiography

Pascal M Lavoie, Amelie Stritzke, Joseph Ting, Mohammad Jabr, Amish Jain, Eddie Kwan, Ela Chakkarapani, Paul Brooks, Rollin Brant, Patrick J McNamara, …

PloS one, Vol.10(10), pp.e0141015-e0141015

2015

DOI: 10.1371/journal.pone.0141015

PMCID: PMC4619855

PMID: 26496361

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Abstract

To compare the effect of oral glucose given with or without facilitated tucking (FT), versus placebo (water) to facilitate image acquisition during a targeted neonatal echocardiography (TNE). Factorial, double blind, randomized controlled trial. Tertiary neonatal intensive care unit (NICU). Infants born between 26 and 42 weeks of gestation (GA). One of four treatment groups: oral water (placebo), oral glucose (25%), facilitated tucking with oral water or facilitated tucking with oral glucose, during a single, structured TNE. All infants received a soother. Change in Behavioral Indicators of Infant Pain (BIIP) scores. 104 preterm infants were randomized (mean ± SD GA: 33.4 ± 3.5 weeks). BIIP scores remained low during the echocardiography scan (median, [IQ range]: 0, [0 to 1]). There were no differences in the level of agitation of infants amongst the treatment groups, with estimated reductions in mean BIIP relative to control of 0.27 (95%CI -0.40 to 0.94) with use of oral glucose and .04 (-0.63 to 0.70) with facilitated tucking. There were also no differences between treatment groups in the quality and duration of the echocardiography scans. In stable infants in the NICU, a TNE can be performed with minimal disruption in a majority of cases, simply by providing a soother. The use of 25% glucose water in this context did not provide further benefit in reducing agitation and improving image acquisition. Clinical Trials.gov: NCT01253889.

Infant, Premature - psychology

Double-Blind Method

Pain - prevention & control

Humans

Infant

Male

Echocardiography - nursing

Intensive Care, Neonatal

Intensive Care Units, Neonatal

Psychomotor Agitation - physiopathology

Pain - physiopathology

Echocardiography - psychology

Female

Glucose - therapeutic use

Psychomotor Agitation - prevention & control

Pain Measurement

Infant, Newborn

Details

Title: Subtitle: A Randomized Controlled Trial of the Use of Oral Glucose with or without Gentle Facilitated Tucking of Infants during Neonatal Echocardiography
Creators: Pascal M Lavoie - Children's & Women's Health Centre of British Columbia, Vancouver, Canada; Department of Pediatrics/Division of Neonatology, University of British Columbia, Vancouver, Canada; Child & Family Research Institute, Vancouver, Canada
Amelie Stritzke - Children's & Women's Health Centre of British Columbia, Vancouver, Canada; Department of Pediatrics/Division of Neonatology, University of British Columbia, Vancouver, Canada
Joseph Ting - Children's & Women's Health Centre of British Columbia, Vancouver, Canada; Department of Pediatrics/Division of Neonatology, University of British Columbia, Vancouver, Canada; Child & Family Research Institute, Vancouver, Canada
Mohammad Jabr - Children's & Women's Health Centre of British Columbia, Vancouver, Canada; Department of Pediatrics/Division of Neonatology, University of British Columbia, Vancouver, Canada
Amish Jain - Department of Pediatrics/Division of Neonatology, University of Toronto, Ontario, Canada
Eddie Kwan - Department of Pharmacy, Children's & Women's Health Centre of British Columbia, Vancouver, Canada
Ela Chakkarapani - Children's & Women's Health Centre of British Columbia, Vancouver, Canada
Paul Brooks - Children's & Women's Health Centre of British Columbia, Vancouver, Canada; Department of Pediatrics/Division of Cardiology, University of British Columbia, Vancouver, Canada
Rollin Brant - Child & Family Research Institute, Vancouver, Canada; Department of Statistics, University of British Columbia, Vancouver, Canada
Patrick J McNamara - Department of Pediatrics/Division of Neonatology, University of Toronto, Ontario, Canada
Liisa Holsti - Child & Family Research Institute, Vancouver, Canada; Department of Occupational Science and Occupational Therapy, University of British Columbia, Vancouver, Canada
Resource Type: Journal article
Publication Details: PloS one, Vol.10(10), pp.e0141015-e0141015
DOI: 10.1371/journal.pone.0141015
PMID: 26496361
PMCID: PMC4619855
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Publisher: Public Library of Science
Grant note: 110938-1 / Canadian Institutes of Health Research 123478-1 / Canadian Institutes of Health Research
Language: English
Date published: 2015
Academic Unit: Stead Family Department of Pediatrics; Neonatology; Internal Medicine
Record Identifier: 9984093601502771

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