Journal article
A Relationship between Metabolism in Frontal Lobes and Cerebellum in Normal Subjects Studied with PET
Journal of cerebral blood flow and metabolism, Vol.8(6), pp.774-782
06/29/2016
DOI: 10.1038/jcbfm.1988.132
PMID: 3263982
Abstract
Lesions of one cerebral hemisphere are associated with decreased glucose metabolism, oxygen metabolism, and blood flow in the contralateral cerebellar hemisphere. We used positron emission tomography to look for a functional relationship in cerebral metabolism between the cerebral cortex and the contralateral cerebellum in normal human subjects. Twenty-four normal subjects were scanned with [18F]fluoro-2-deoxy-D-glucose while in a resting state. Asymmetry in local CMRglu (LCMRglu) in the frontal cortex was strongly correlated with asymmetry in LCMRglu in the opposite direction in the cerebellar hemispheres ( r = −0.60, p < 0.001). Widespread subregions of the frontal cortex were found to contribute to this relationship. Considering these results together with previous studies demonstrating that frontal lesions are associated with decreased metabolism in the contralateral cerebellum, we conclude that the frontal cortex exerts a strong modulating influence on metabolism in the contralateral cerebellum in normal subjects, and that this influence may be asymmetrical.
Details
- Title: Subtitle
- A Relationship between Metabolism in Frontal Lobes and Cerebellum in Normal Subjects Studied with PET
- Creators
- Larry JunckSid GilmanJill R Rothley - Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, U.S.AAnnette T Betley - Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, U.S.ARobert A Koeppe - Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, U.S.ARichard D Hichwa - Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, U.S.A
- Resource Type
- Journal article
- Publication Details
- Journal of cerebral blood flow and metabolism, Vol.8(6), pp.774-782
- DOI
- 10.1038/jcbfm.1988.132
- PMID
- 3263982
- ISSN
- 0271-678X
- eISSN
- 1559-7016
- Language
- English
- Date published
- 06/29/2016
- Academic Unit
- Radiology; Research Administration; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984213446702771
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