Journal article
A Remote Time-Restricted Eating and Mindfulness Intervention Addressing Risk Factors Associated with Early-Onset Colorectal Cancer Demonstrates Feasibility and Acceptability among Young Adults: A Randomized Controlled Pilot Trial
Nutrition and cancer, Vol.77(10), pp.1142-1161
11/26/2025
DOI: 10.1080/01635581.2025.2557642
PMCID: PMC12604677
PMID: 40924443
Abstract
Increased adiposity and chronic psychosocial stress (CPS) are plausible modifiable contributors of the recent increase in early-onset colorectal cancer (EOCRC). We conducted an 8-week randomized controlled pilot trial evaluating the feasibility and acceptability of time restricted eating (TRE) (daily ad libitum eating between 12-8pm) and Mindfulness ("Mindfulness for Beginners" course from the Calm
app) among young adults. Participants were randomized to the following groups: TRE (
= 10); Mindfulness (
= 11); TRE & Mindfulness (
= 11); or Control (
= 11). Forty-three participants were randomized. Acceptability of the trial was high and attrition rates were low (7%). Participants completed 92% of the Mindfulness course, and 90-92% were adherent to the TRE intervention. PSS decreased significantly within the TRE, Mindfulness, and TRE & Mindfulness arms from pre- to post-intervention, but not within the Control arm. The TRE & Mindfulness arm had improvements in visceral fat mass, fasting insulin, fasting glucose, HOMA-IR, hemoglobin A1c, and fecal calprotectin, pre- to post-intervention, compared to the TRE and Mindfulness arms. This study was feasible and well-accepted. Results were promising for the combined TRE & Mindfulness protocol showing superior improvements in perceived stress, visceral adiposity, cardiometabolic and inflammatory markers. It is important to note the limited generalizability of our sample.
Details
- Title: Subtitle
- A Remote Time-Restricted Eating and Mindfulness Intervention Addressing Risk Factors Associated with Early-Onset Colorectal Cancer Demonstrates Feasibility and Acceptability among Young Adults: A Randomized Controlled Pilot Trial
- Creators
- Manoela Lima Oliveira - University of Illinois Urbana-ChampaignKate Cares - University of Illinois ChicagoAlyshia Hamm - University of Illinois ChicagoSaba Nadeem - University of Illinois ChicagoDana Bogseth - University of Illinois ChicagoBrooke Klatkiewicz - University of Illinois ChicagoTony Overhiser - University of Illinois ChicagoChristel Elias - University of Illinois ChicagoYanhui Li - University of Illinois ChicagoRui Guo - University of Illinois ChicagoVanessa M Oddo - University of Illinois ChicagoAlana Biggers - University of Illinois ChicagoKeith B Naylor - University of Illinois ChicagoZhengjia Chen - University of Illinois ChicagoLacey Pezley - University of Illinois ChicagoMaigh Attre - University of Illinois ChicagoBeatriz Peñalver Bernabé - University of Illinois ChicagoKelsey Gabel - University of Illinois ChicagoLisa K Sharp - University of Illinois ChicagoKestutis Bendinskas - State University of New York at OswegoDylan Webber - State University of New York at OswegoMark B Lockwood - University of Illinois Urbana-ChampaignNathaniel D M Jenkins - University of IowaLisa M Tussing-Humphreys - University of Illinois Chicago
- Resource Type
- Journal article
- Publication Details
- Nutrition and cancer, Vol.77(10), pp.1142-1161
- DOI
- 10.1080/01635581.2025.2557642
- PMID
- 40924443
- PMCID
- PMC12604677
- NLM abbreviation
- Nutr Cancer
- ISSN
- 0163-5581
- eISSN
- 1532-7914
- Publisher
- ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
- Grant note
- National Cancer Institute: T32CA057699, R01CA204808, U54CA202997
This work was funded by the National Cancer Institute T32CA057699, R01CA204808, U54CA202997. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
- Language
- English
- Electronic publication date
- 09/09/2025
- Date published
- 11/26/2025
- Academic Unit
- Center for Social Science Innovation; Injury Prevention Research Center; Health, Sport, and Human Physiology
- Record Identifier
- 9984962640902771
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