Journal article
A Review of Advances in Lung Function Imaging and Its Applications for Functional Lung Avoidance in Radiation Therapy
Seminars in nuclear medicine, Vol.55(6), pp.1046-1057
11/2025
DOI: 10.1053/j.semnuclmed.2025.09.002
PMID: 41006110
Abstract
Lung function imaging, with a specific focus on quantifying ventilation and perfusion, has gained increasing recognition within the field of functional lung avoidance radiation therapy (FLART), a technique that incorporates functional information to minimize radiation exposure to healthy lung tissue. This review critically analyzes multiple categories of clinical imaging modalities, including nuclear medicine imaging, computed tomography, and magnetic resonance imaging, which can assess the spatial distribution of lung functions. Each modality presents unique strengths in providing valuable information for FLART, yet they also have their limitations, which are detailed in this review. Furthermore, we discuss the current challenges limiting the broader implementation of lung function imaging and FLART in clinical practice. Future research directions and potential solutions are also outlined, to enable lung function imaging to play a more significant role in FLART, leading to personalized lung cancer management and improved patient outcomes.
Details
- Title: Subtitle
- A Review of Advances in Lung Function Imaging and Its Applications for Functional Lung Avoidance in Radiation Therapy
- Creators
- Zhi Chen - Hong Kong Polytechnic UniversityZihan Li - Hong Kong Polytechnic UniversityYu-Hua Huang - Hong Kong Polytechnic UniversityTianyu Xiong - Hong Kong Polytechnic UniversityXinzhi Teng - Hong Kong Polytechnic UniversityBing Li - Henan Cancer HospitalJohn Kipritidis - Royal North Shore HospitalPaul J Keall - The University of SydneyJoseph M Reinhardt - University of IowaHong Ge - Henan Cancer HospitalGe Ren - Hong Kong Polytechnic UniversityJing Cai - Hong Kong Polytechnic University
- Resource Type
- Journal article
- Publication Details
- Seminars in nuclear medicine, Vol.55(6), pp.1046-1057
- DOI
- 10.1053/j.semnuclmed.2025.09.002
- PMID
- 41006110
- NLM abbreviation
- Semin Nucl Med
- ISSN
- 1558-4623
- eISSN
- 1558-4623
- Publisher
- W B SAUNDERS CO-ELSEVIER INC
- Grant note
- General Research Fund (GRF) from the University Grants Committee: 15103520, 15121524 Health and Medical Research Fund (HMRF)from the Health Bureau, the Government of the Hong Kong Special Administrative Region: 07183266, 09200576 Hong Kong Polytechnic University: P0043001 Shenzhen Science and Technology Program: JCYJ20230807140403007 Henan Provincial Medical Science and Technology Research Project: SBGJ202102056, SBGJ202103038 Natural Science Foundation of Henan Province of China: 222300420575, 232300420231 Key Technologies R&D Programme of Henan Province: 222102310015 Overseas Study Personnel Research Excellence Funding and Entrepreneurship Start-up Project of Henan Province: 37
This work was supported in part by (1) General Research Fund (GRF 15103520 and 15121524) from the University Grants Committee, (2) Health and Medical Research Fund (HMRF 07183266 and 09200576) from the Health Bureau, the Government of the Hong Kong Special Administrative Region, (3) Projects of RISA (P0043001) from The Hong Kong Polytechnic University, (4) Shenzhen Science and Technology Program (JCYJ20230807140403007) , (5) Henan Provincial Medical Science and Technology Research Project (SBGJ202102056 and SBGJ202103038) , (6) Natural Science Foundation of Henan Province of China (222300420575 and 232300420231) , (7) Key Technologies R&D Programme of Henan Province (222102310015) , and (8) Overseas Study Personnel Research Excellence Funding and Entrepreneurship Start-up Project of Henan Province (No. 37) .
- Language
- English
- Electronic publication date
- 09/25/2025
- Date published
- 11/2025
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology
- Record Identifier
- 9984964741902771
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