A Review of Periostin in Orthopedics

Mark Wishman; William M. Sgrignoli; Brendan M. Patterson; James V. Nepola; Brian R. Wolf; Carter M. Lane; Maria Bozoghlian; Mitchell Coleman; Joseph W. Galvin

doi:10.1016/j.ocarto.2025.100600

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A Review of Periostin in Orthopedics

Mark Wishman, William M. Sgrignoli, Brendan M. Patterson, James V. Nepola, Brian R. Wolf, Carter M. Lane, Maria Bozoghlian, Mitchell Coleman and Joseph W. Galvin

Osteoarthritis and cartilage open, Vol.7(2), 100600

06/2025

DOI: 10.1016/j.ocarto.2025.100600

PMCID: PMC11985005

PMID: 40213472

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Abstract

Objective This review explores periostin (POSTN), a matricellular protein integral to developmental physiological, and pathological processes, by examining its structure, function, and emerging roles in orthopedic and non-musculoskeletal pathologies. It investigates POSTN's potential as a biomarker and therapeutic target in orthopedic diseases, with a focus on post-traumatic osteoarthritis (PTOA), addressing the need for a comprehensive analysis of its current and future clinical significance in orthopedic and musculoskeletal health. Methods A comprehensive literature review was performed, synthesizing current available literature surrounding POSTN, including findings from human and rodent studies. Data were compiled from multiple large publication databases to provide a broad and current perspective on its roles and applications. Results POSTN is upregulated in osteoarthritic cartilage and synovial fluid following joint injuries, such as ACL ruptures and anterior shoulder instability events. It promotes cartilage matrix degradation by upregulating catabolic enzymes and inflammatory pathways. Therapeutic silencing of POSTN with siRNA reduces inflammatory mediator expression and mitigates cartilage degeneration in rodent models. POSTN's differential expression across injury stages suggests its potential utility as a biomarker for monitoring disease progression. Conclusions POSTN is pivotal in musculoskeletal development, fracture healing and bone biology, offering potential as a prognostic biomarker for orthopedic conditions and a tool for monitoring disease progression. Its significant role in PTOA development suggests that targeting POSTN and its downstream inflammatory mediators offer innovative strategies for managing PTOA, warranting further research and clinical exploration.

Osteoarthritis

Periostin

Biomarker

Cartilage

Fracture

Details

Title: Subtitle: A Review of Periostin in Orthopedics
Creators: Mark Wishman - University of Iowa
William M. Sgrignoli - University of Iowa
Brendan M. Patterson - University of Iowa
James V. Nepola - University of Iowa
Brian R. Wolf - University of Iowa
Carter M. Lane - University of Iowa
Maria Bozoghlian - University of Iowa
Mitchell Coleman - University of Iowa
Joseph W. Galvin - University of Iowa
Resource Type: Journal article
Publication Details: Osteoarthritis and cartilage open, Vol.7(2), 100600
DOI: 10.1016/j.ocarto.2025.100600
PMID: 40213472
PMCID: PMC11985005
NLM abbreviation: Osteoarthr Cartil Open
ISSN: 2665-9131
eISSN: 2665-9131
Publisher: ELSEVIER
Language: English
Electronic publication date: 03/17/2025
Date published: 06/2025
Academic Unit: Orthopedics and Rehabilitation; Radiation Oncology; Physical Therapy and Rehabilitation Science
Record Identifier: 9984801617802771

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