Journal article
A Role for Dystroglycan in Basement Membrane Assembly
Cell (Cambridge), Vol.95(6), pp.859-870
1998
DOI: 10.1016/S0092-8674(00)81708-0
PMID: 9865703
Abstract
Basement membranes are composed of ordered arrays of characteristic extracellular matrix proteins, but little is known about the assembly of these structures in vivo. We have investigated the function of dystroglycan, a cell-surface laminin receptor expressed by cells contacting basement membranes in developing and adult tissues. We find that dystroglycan is required for the formation of a basement membrane in embryoid bodies. Our results further indicate that dystroglycan–laminin interactions are prerequisite for the deposition of other basement membrane proteins. Dystroglycan may exert its influence on basement membrane assembly by binding soluble laminin and organizing it on the cell surface. These data establish a role for dystroglycan in the assembly of basement membranes and suggest fundamental mechanisms underlying this process.
Details
- Title: Subtitle
- A Role for Dystroglycan in Basement Membrane Assembly
- Creators
- Michael D Henry - Howard Hughes Medical Institute, Department of Physiology and Biophysics, Department of Neurology, The University of Iowa College of Medicine, Iowa City, Iowa 52242 USAKevin P Campbell - Howard Hughes Medical Institute, Department of Physiology and Biophysics, Department of Neurology, The University of Iowa College of Medicine, Iowa City, Iowa 52242 USA
- Resource Type
- Journal article
- Publication Details
- Cell (Cambridge), Vol.95(6), pp.859-870
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0092-8674(00)81708-0
- PMID
- 9865703
- ISSN
- 0092-8674
- eISSN
- 1097-4172
- Language
- English
- Date published
- 1998
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pathology; Iowa Neuroscience Institute; Radiation Oncology; Urology; Internal Medicine
- Record Identifier
- 9984068384102771
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