Journal article
A Scoping Review of Genetic Risk Factors Possibly Impacting Virally Induced Brain Injury After Zika Infection
Pediatric research, Vol.98(7), pp.2530-2535
12/2025
DOI: 10.1038/s41390-025-04252-1
PMID: 40593187
Abstract
IntroductionThe severity of virally induced prenatal brain injury, even among dizygotic twins, varies according to individual and maternal risk and protective factors, including genomics.ObjectiveThis scoping review aims to analyze data on genetic susceptibility to neurological outcomes in children exposed in utero to Zika virus.MethodsWe followed JBI methodology for this scoping review. A search in PubMed, Scopus, CINAHL, Web of Science, Academic Search Ultimate, Agricola, Health Source: Nursing/Academic Edition, and Psychology and Behavioral Sciences Collection was conducted. Three reviewers independently screened studies using the Rayyan platform. Studies on gene mutations impacting brain injury after Zika virus infection were included.ResultsThirteen articles identifying candidate genes related to brain injury were reviewed. Twenty-three genes were implicated in modulating susceptibility to prenatal brain injury, including six maternal and 17 infant genes.ConclusionsMaternal and fetal genetic factors likely contribute susceptibility to virally induced prenatal brain injury. Analyzing polygenic risk could aid in future screening programs to identify individuals at risk. This information may eventually be integrated into clinical data, helping healthcare providers, families, and patients understand how to personalize care for better outcomes.ImpactThis paper evaluates available evidence about the relationship between genetic susceptibility and neurological consequences of Zika virus exposure during pregnancy.After performing a scoping review, we identified 13 articles describing candidate genes that potentially contribute to the development of virally induced brain injury after prenatal Zika infection. Of the genes identified, six were associated with maternal risks, while 17 were linked to the fetus.Maternal and prenatal genetic factors could increase the risk of virally induced prenatal brain injury.Future research should investigate factors that can modify disease pathogenesis toward the goal of reducing the global impact of brain injury.
Details
- Title: Subtitle
- A Scoping Review of Genetic Risk Factors Possibly Impacting Virally Induced Brain Injury After Zika Infection
- Creators
- Fernanda J. P. Marques - Sarah Network of Rehabilitation HospitalsJanet Ruan - Children's NationalRozel B. Razal - University of the Philippines ManilaMarcio Leyser - University of Iowa Health CareYoussef A. Kousa - Children's National
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.98(7), pp.2530-2535
- DOI
- 10.1038/s41390-025-04252-1
- PMID
- 40593187
- NLM abbreviation
- Pediatr Res
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- Publisher
- Springer Nature
- Number of pages
- 6
- Grant note
- PING Consortium P50HD105328 / IDDRC P50 Rio de Janeiro, Brazil, Children's National Research Institute, Washington, D.C., University of Florida College of Medicine - Jacksonville K08NS119882; L40HD102847 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Electronic publication date
- 07/01/2025
- Date published
- 12/2025
- Academic Unit
- Stead Family Department of Pediatrics
- Record Identifier
- 9984946630202771
Metrics
12 Record Views