Journal article
A Second Chance for a PPAR gamma Targeted Therapy?
Circulation research, Vol.110(1), pp.8-11
01/06/2012
DOI: 10.1161/RES.0b013e3182435d88
PMCID: PMC3583552
PMID: 22223206
Abstract
A new class of non-agonist ligands target the transcription factor PPAR gamma and promote expression of insulin-sensitizing adipokines. They have potent antidiabetic actions, yet they lack several of the adverse effects commonly associated with thiazolidinediones. The ligands may represent a new class of anti-diabetes medications that preserve the most beneficial effects of PPAR gamma activation without imparting major side effects, which have limited the clinical usefulness of thiazolidinediones.
Details
- Title: Subtitle
- A Second Chance for a PPAR gamma Targeted Therapy?
- Creators
- Andrew W. Norris - Roy J. and Lucille A. Carver College of MedicineCurt D. Sigmund - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Circulation research, Vol.110(1), pp.8-11
- DOI
- 10.1161/RES.0b013e3182435d88
- PMID
- 22223206
- PMCID
- PMC3583552
- NLM abbreviation
- Circ Res
- ISSN
- 0009-7330
- eISSN
- 1524-4571
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 4
- Grant note
- P01HL062984 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01DK081548 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R37 HL048058; R01 HL061446; HL084207; P01 HL062984; R01 HL048058; HL062984; HL048058; P01 HL084207; HL061446 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) DK081548; R01 DK081548 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 01/06/2012
- Academic Unit
- Molecular Physiology and Biophysics; Endocrinology and Diabetes; Stead Family Department of Pediatrics; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984293082802771
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