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A Sickle Cell Disease Patient with Severe Tricuspid Regurgitation and Early Developed Pulmonary Hypertension
Journal article   Open access   Peer reviewed

A Sickle Cell Disease Patient with Severe Tricuspid Regurgitation and Early Developed Pulmonary Hypertension

Gaurang Vaidya, Muhammad Sarwar, Zongxia Sun, Tiemin Wei and Kan Liu
Internal medicine (Tokyo, 1992), Vol.54(19), pp.2459-2462
01/01/2015
DOI: 10.2169/internalmedicine.54.4463
PMID: 26424303
url
https://doi.org/10.2169/internalmedicine.54.4463View
Published (Version of record) Open Access

Abstract

Pulmonary hypertension (PH) worsens the mortality of the patients with sickle cell disease (SCD). The exact mechanism of PH development/progression in SCD, including the role of tricuspid regurgitation (TR), remains unclear. We herein report an unusual SCD case, complicated by chronic thromboembolic disorder, who developed severe TR and an accelerated progression of PH. Tricuspid valve surgery significantly ameliorated the patient's symptoms and reduced hospital readmission. The early detection and management of the reversible disorder accelerating the PH development in SCD patients may alter the clinical course, improve the quality of life, and potentially affect the long-term outcome.
General & Internal Medicine Life Sciences & Biomedicine Medicine, General & Internal Science & Technology

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