Journal article
A Simplified Geometric Model to Predict Nasal Spray Deposition in Children and Adults
AAPS PharmSciTech, Vol.19(7), pp.2767-2777
10/2018
DOI: 10.1208/s12249-018-1031-2
PMID: 29948982
Abstract
A mathematical approach was developed to estimate spray deposition patterns in the nasal cavity based on the geometric relationships between the emitted spray plume and the anatomical dimensions of the nasal valve region of the nasal cavity. Spray plumes were assumed to be spherical cones and the nasal valve region was approximated as an ellipse. The effect of spray plume angle (15-85°) on the fraction of the spray able to pass through the nasal valve (deposition fraction) was tested for a variety of nasal valve (ellipse) shapes and cross-sectional areas based on measured dimensions from pediatric and adult nasal cavities. The effect of the distances between the tip of the nasal spray device and the nasal valve (0.2-1.9 cm) on the deposition fraction was also tested. Simulation results show that (1) decreasing spray plume angles resulted in higher deposition fractions, (2) deposition fraction was inversely proportional to the spray distance and the nasal valve (ellipse) major/minor axis ratio, and (3) for fixed major/minor axis ratios, improved deposition occurred with larger nasal valve cross-sectional areas. For a typical adult nasal valve, plume angles of less than 40° emitted from a distance of 1 cm resulted depositions greater than 90% within the main nasal cavity, whereas for a 12-year-old child, only the most narrow plume angles (< 20°) administered resulted in significant deposition beyond the nasal valve.
Details
- Title: Subtitle
- A Simplified Geometric Model to Predict Nasal Spray Deposition in Children and Adults
- Creators
- Mow Yee Foo - Novartis Pharmaceuticals, Shanghai, ChinaNamita Sawant - College of Pharmacy, University of Iowa, 115 S. Grand Ave., Iowa City, Iowa, 52242, USAEllen Overholtzer - College of Pharmacy, University of Iowa, 115 S. Grand Ave., Iowa City, Iowa, 52242, USAMaureen D Donovan - College of Pharmacy, University of Iowa, 115 S. Grand Ave., Iowa City, Iowa, 52242, USA. maureen-donovan@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- AAPS PharmSciTech, Vol.19(7), pp.2767-2777
- DOI
- 10.1208/s12249-018-1031-2
- PMID
- 29948982
- NLM abbreviation
- AAPS PharmSciTech
- ISSN
- 1530-9932
- eISSN
- 1530-9932
- Publisher
- United States
- Language
- English
- Date published
- 10/2018
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984065311702771
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