Journal article
A Single Injection of Platelet-Rich Plasma Injection for the Treatment of Stress Urinary Incontinence in Females: A Randomized Placebo-Controlled Trial
Urology (Ridgewood, N.J.), Vol.193, pp.63-68
11/2024
DOI: 10.1016/j.urology.2024.06.047
PMCID: PMC12826440
PMID: 38942391
Abstract
To determine the efficacy of a single injection of platelet-rich plasma into the anterior vaginal wall at the mid-urethra compared to placebo, as there is emerging evidence that platelet-rich plasma may help treat female stress urinary incontinence.
This was a single-blind, randomized, placebo-controlled clinical trial at a single institution. Females with bothersome, demonstrable stress-predominant urinary incontinence were enrolled. Participants were randomized to either injection of 5 mL autologous platelet-rich plasma or saline at the anterior vaginal wall at the mid-urethra. The primary outcome was composite treatment success at six months, defined as a negative cough stress test and an answer of “much better” or “very much better” on the Patient’s Global Impression of Improvement.
Fifty patients were enrolled in the study and randomized to the platelet-rich plasma group (n = 25) or the saline placebo group (n = 25). There was no statistically significant difference in the primary outcome between the two groups. Adverse events were minor, and the rate of adverse events was similar between both groups.
In this randomized placebo-controlled study, we were unable to demonstrate a difference in stress urinary incontinence treatment success between platelet-rich plasma and saline injections. At this time, there is insufficient evidence to offer a one-time platelet-rich plasma injection into the anterior vaginal wall for treatment of female stress urinary incontinence.
Details
- Title: Subtitle
- A Single Injection of Platelet-Rich Plasma Injection for the Treatment of Stress Urinary Incontinence in Females: A Randomized Placebo-Controlled Trial
- Creators
- Leah Ashton - Medical University of South CarolinaHannah Nataksuka - University of Iowa Hospitals & ClinicsColin M. Johnson - University of IowaKimberly Kenne - University of Iowa Hospitals & ClinicsKarl J. Kreder - University of IowaRyan Kruse - University of Iowa Hospitals & ClinicsLinder Wendt - University of IowaElizabeth B. Takacs - University of Iowa Hospitals & ClinicsAnnah J. Vollstedt - University of Iowa Hospitals & Clinics
- Resource Type
- Journal article
- Publication Details
- Urology (Ridgewood, N.J.), Vol.193, pp.63-68
- DOI
- 10.1016/j.urology.2024.06.047
- PMID
- 38942391
- PMCID
- PMC12826440
- NLM abbreviation
- Urology
- ISSN
- 0090-4295
- eISSN
- 1527-9995
- Publisher
- Elsevier Inc; NEW YORK
- Grant note
- University of Iowa Department of Urology Intramural GrantUniversity of Iowa Clinical and Translational Science AwardNIH: UM1TR004403
Funding was provided by the University of Iowa Department of Urology Intramural Grant and the University of Iowa Clinical and Translational Science Award granted with funds from the NIH (UM1TR004403)
- Language
- English
- Electronic publication date
- 06/26/2024
- Date published
- 11/2024
- Academic Unit
- Orthopedics and Rehabilitation; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984649058002771
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