Journal article
A Stable Isotope Biomarker of Marine Food Intake Captures Associations between n-3 Fatty Acid Intake and Chronic Disease Risk in a Yup'ik Study Population, and Detects New Associations with Blood Pressure and Adiponectin
The Journal of nutrition, Vol.144(5), pp.706-713
2014
DOI: 10.3945/jn.113.189381
PMCID: PMC3985827
PMID: 24598880
Abstract
The nitrogen isotope ratio (δ(15)N) of RBCs has been proposed as a biomarker of marine food intake in Yup'ik people based on strong associations with RBC eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). However, EPA and DHA derive from marine fats, whereas elevated δ(15)N derives from marine protein, and these dietary components may have different biologic effects. Whether δ(15)N is similarly associated with chronic disease risk factors compared with RBC EPA and DHA is not known. We used covariate-adjusted linear models to describe biomarker associations with chronic disease risk factors in Yup'ik people, first in a smaller (n = 363) cross-sectional study population using RBC EPA, DHA, and δ(15)N, and then in a larger (n = 772) cross-sectional study population using δ(15)N only. In the smaller sample, associations of RBC EPA, DHA, and δ(15)N with obesity and chronic disease risk factors were similar in direction and significance: δ(15)N was positively associated with total, HDL, and LDL cholesterol, apolipoprotein A-I, and insulin-like growth factor binding protein-3 (IGFBP-3), and inversely associated with triglycerides. Based on comparisons between covariate-adjusted β-coefficients, EPA was more strongly associated with circulating lipids and lipoproteins, whereas δ(15)N was more strongly associated with adipokines, the inflammatory marker interleukin-6, and IGFBP-3. In the larger sample there were new findings for this population: δ(15)N was inversely associated with blood pressure and there was a significant association (with inverse linear and positive quadratic terms) with adiponectin. In conclusion, δ(15)N is a valid measure for evaluating associations between EPA and DHA intake and chronic disease risk in Yup'ik people and may be used in larger studies. By measuring δ(15)N, we report beneficial associations of marine food intake with blood pressure and adiponectin, which may contribute to a lower incidence of some chronic diseases in Yup'ik people.
Details
- Title: Subtitle
- A Stable Isotope Biomarker of Marine Food Intake Captures Associations between n-3 Fatty Acid Intake and Chronic Disease Risk in a Yup'ik Study Population, and Detects New Associations with Blood Pressure and Adiponectin
- Creators
- Diane M O'BRIEN - Center for Alaska Native Health Research, Institute of Arctic Biology, United StatesAlan R Kristal - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United StatesSarah H Nash - Center for Alaska Native Health Research, Institute of Arctic Biology, United StatesScarlett E Hopkins - Center for Alaska Native Health Research, Institute of Arctic Biology, United StatesBret R Luick - Center for Alaska Native Health Research, Institute of Arctic Biology, United StatesKimber L Stanhope - Department of Molecular Biosciences, School of Veterinary Medicine, and Department of Nutrition, University of California, Davis, Davis, CA, United StatesPeter J Havel - Department of Molecular Biosciences, School of Veterinary Medicine, and Department of Nutrition, University of California, Davis, Davis, CA, United StatesBert B Boyer - Center for Alaska Native Health Research, Institute of Arctic Biology, United States
- Resource Type
- Journal article
- Publication Details
- The Journal of nutrition, Vol.144(5), pp.706-713
- Publisher
- American Society for Nutrition
- DOI
- 10.3945/jn.113.189381
- PMID
- 24598880
- PMCID
- PMC3985827
- ISSN
- 0022-3166
- eISSN
- 1541-6100
- Language
- English
- Date published
- 2014
- Academic Unit
- Epidemiology; Center for Social Science Innovation
- Record Identifier
- 9984214852702771
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