Journal article
A Systematic Review and Meta-Analysis of Decompression Sickness in Altitude Physiological Training
Aerospace medicine and human performance, Vol.89(11), pp.941-951
11/01/2018
DOI: 10.3357/AMHP.5135.2018
PMID: 30352646
Abstract
INTRODUCTION: A review of decompression sickness (DCS) cases associated with the NASA altitude physiological training (APT) program at the Johnson Space Center (JSC) motivated us to place our findings into the larger context of DCS prevalence from other APT centers.METHODS:
We reviewed JSC records from 1999 to 2016 and 14 publications from 1968 to 2004 about DCS prevalence in other APT programs. We performed a meta-analysis of 15 APT profiles (488 cases / 385,116 exposures). We used meta-regression to evaluate the relation between estimated exposures and probability
of DCS in a test group, accounting for the heterogeneity between studies.RESULTS: Our in-house review identified 6 Type I DCS (1 from an inside observer) and 1 Type II DCS. There were 6 cases in 9560 student hypobaric exposures from 3 NASA training flights; a student pooled prevalence
rate of 0.44 cases / 1000 exposures compared to 1.44 cases / 1000 from 12 published APT profiles. The overall pooled DCS prevalence rate was 1.16 cases / 1000 exposures. There was substantial heterogeneity in DCS prevalence across studies. Denitrogenation time, exposure pressure, and exposure
time were associated with probability of DCS in the meta-regression model.CONCLUSIONS: While the overall DCS prevalence rate is relatively low, there is marked heterogeneity among profiles. The pooled DCS prevalence rate estimate for the NASA profiles was lower than the overall
rate. Variability in APT profile DCS prevalence could be further explained given student level and additional test-level covariates.Conkin J, Sanders RW, Koslovsky MD, Wear ML, Kozminski AG, Abercromby AFJ. A systematic review and meta-analysis of decompression sickness in altitude
physiological training. Aerosp Med Hum Perform. 2018; 89(11):941-951.
Details
- Title: Subtitle
- A Systematic Review and Meta-Analysis of Decompression Sickness in Altitude Physiological Training
- Creators
- Johnny ConkinRobert W. SandersMatthew D. KoslovskyMary L. WearAndrew G. KozminskiAndrew F. J. Abercromby
- Resource Type
- Journal article
- Publication Details
- Aerospace medicine and human performance, Vol.89(11), pp.941-951
- Publisher
- Aerospace Medical Association
- DOI
- 10.3357/AMHP.5135.2018
- PMID
- 30352646
- ISSN
- 2375-6314
- eISSN
- 2375-6322
- Number of pages
- 11
- Language
- English
- Date published
- 11/01/2018
- Academic Unit
- Emergency Medicine
- Record Identifier
- 9984702823002771
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