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A Test of Odor Fluency in Patients with Alzheimer's and Huntington's Disease
Journal article   Peer reviewed

A Test of Odor Fluency in Patients with Alzheimer's and Huntington's Disease

Anna Bacon Moore, Jane S Paulsen and Claire Murphy
Journal of clinical and experimental neuropsychology, Vol.21(3), pp.341-351
06/01/1999
DOI: 10.1076/jcen.21.3.341.918
PMID: 10474173

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Abstract

In the present study, an olfactory analog to the verbal fluency test was designed and administered to 40 patients with Alzheimer's disease (AD) and 11 patients with Huntington's disease (HD). Because onset of AD is typically in the sixties while onset of HD is typically in the mid-thirties, the patient groups had their own control group, an older (ONC) and younger (YNC) control group, respectively. Both control groups included 40 participants who were age- and education-matched to their respective patient group. Odor threshold, odor identification, and odor fluency measures were administered to each participant. Results of the study indicate that patients with dementia perform more poorly on all three measures of olfactory functioning. Our results suggest that tests of odor memory show differential performance in healthy and demented patients, leading to the suggestion that tests of olfactory functioning may be useful in detection and diagnosis of neurodegenerative disease.

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