Journal article
A Validated Model of the Pro- and Anti-Inflammatory Cytokine Balancing Act in Articular Cartilage Lesion Formation
Frontiers in Bioengineering and Biotechnology, Vol.3(MAR), pp.25-25
2015
DOI: 10.3389/fbioe.2015.00025
PMCID: PMC4354422
PMID: 25806365
Abstract
Traumatic injuries of articular cartilage result in the formation of a cartilage lesion and contribute to cartilage degeneration and the risk of osteoarthritis (OA). A better understanding of the framework for the formation of a cartilage lesion formation would be helpful in therapy development. Toward this end, we present an age and space-structured model of articular cartilage lesion formation after a single blunt impact. This model modifies the reaction-diffusion-delay models in Graham et al. ( 2012 ) (single impact) and Wang et al. ( 2014 ) (cyclic loading), focusing on the “balancing act” between pro- and anti-inflammatory cytokines. Age structure is introduced to replace the delay terms for cell transitions used in these earlier models; we find age structured models to be more flexible in representing the underlying biological system and more tractable computationally. Numerical results show a successful capture of chondrocyte behavior and chemical activities associated with the cartilage lesion after the initial injury; experimental validation of our computational results is presented. We anticipate that our in silico model of cartilage damage from a single blunt impact can be used to provide information that may not be easily obtained through in in vivo or in vitro studies.
Details
- Title: Subtitle
- A Validated Model of the Pro- and Anti-Inflammatory Cytokine Balancing Act in Articular Cartilage Lesion Formation
- Creators
- Xiayi Wang - University of IowaMarc J Brouillette - ,Bruce P Ayati - ,James A Martin - ,
- Resource Type
- Journal article
- Publication Details
- Frontiers in Bioengineering and Biotechnology, Vol.3(MAR), pp.25-25
- DOI
- 10.3389/fbioe.2015.00025
- PMID
- 25806365
- PMCID
- PMC4354422
- NLM abbreviation
- Front Bioeng Biotechnol
- ISSN
- 2296-4185
- eISSN
- 2296-4185
- Publisher
- Frontiers Media S.A
- Language
- English
- Date published
- 2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Orthopedics and Rehabilitation; Mathematics
- Record Identifier
- 9983985972502771
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