Journal article
A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD
Scientific reports, Vol.13(1), 8228
05/22/2023
DOI: 10.1038/s41598-023-32216-0
PMCID: PMC10203309
PMID: 37217548
Abstract
Accelerated progression of chronic obstructive pulmonary disease (COPD) is associated with increased risks of hospitalization and death. Prognostic insights into mechanisms and markers of progression could facilitate development of disease-modifying therapies. Although individual biomarkers exhibit some predictive value, performance is modest and their univariate nature limits network-level insights. To overcome these limitations and gain insights into early pathways associated with rapid progression, we measured 1305 peripheral blood and 48 bronchoalveolar lavage proteins in individuals with COPD [n = 45, mean initial forced expiratory volume in one second (FEV
1
) 75.6 ± 17.4% predicted]. We applied a data-driven analysis pipeline, which enabled identification of protein signatures that predicted individuals at-risk for accelerated lung function decline (FEV
1
decline ≥ 70 mL/year) ~ 6 years later, with high accuracy. Progression signatures suggested that early dysregulation in elements of the complement cascade is associated with accelerated decline. Our results propose potential biomarkers and early aberrant signaling mechanisms driving rapid progression in COPD.
Details
- Title: Subtitle
- A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD
- Creators
- Katarina M. DiLillo - Ann Arbor, MI USAKaty C. Norman - Ann Arbor, MI USAChristine M. Freeman - Ann Arbor, MI USA Ann Arbor, MI USA Ann Arbor, MI USAStephanie A. Christenson - San Francisco, CA USANeil E. Alexis - Chapel Hill, NC USAWayne H. Anderson - Chapel Hill, NC USAIgor Z. Barjaktarevic - Los Angeles, CA USAR. Graham Barr - New York, NY USAAlejandro P. Comellas - Iowa City, IA USAEugene R. Bleecker - Tucson, AZ USARichard C. Boucher - Chapel Hill, NC USADavid J. Couper - Chapel Hill, NC USAGerard J. Criner - Philadelphia, PA USAClaire M. Doerschuk - Chapel Hill, NC USAJ. Michael Wells - Birmingham, AL USAMeiLan K. Han - Ann Arbor, MI USAEric A. Hoffman - Iowa City, IA USANadia N. Hansel - Baltimore, MD USAAnnette T. Hastie - New England Baptist HospitalRobert J. Kaner - New York, NY USAJerry A. Krishnan - Chicago, IL USAWassim W. Labaki - Ann Arbor, MI USAFernando J. Martinez - New York, NY USADeborah A. Meyers - Tucson, AZ USAWanda K. O’Neal - Chapel Hill, NC USAVictor E. Ortega - Scottsdale, AZ USARobert Paine - Salt Lake City, UT USAStephen P. Peters - New England Baptist HospitalPrescott G. Woodruff - San Francisco, CA USAChristopher B. Cooper - Los Angeles, CA USARussell P. Bowler - Denver, CO USAJeffrey L. Curtis - Ann Arbor, MI USA Ann Arbor, MI USA Ann Arbor, MI USAKelly B. Arnold - Ann Arbor, MI USASPIROMICS investigators
- Resource Type
- Journal article
- Publication Details
- Scientific reports, Vol.13(1), 8228
- DOI
- 10.1038/s41598-023-32216-0
- PMID
- 37217548
- PMCID
- PMC10203309
- NLM abbreviation
- Sci Rep
- ISSN
- 2045-2322
- eISSN
- 2045-2322
- Publisher
- Nature Publishing Group UK
- Language
- English
- Date published
- 05/22/2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
- Record Identifier
- 9984419358702771
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