Journal article
A brain basis for musical hallucinations
Cortex, Vol.52(1), pp.86-97
03/01/2014
DOI: 10.1016/j.cortex.2013.12.002
PMCID: PMC3969291
PMID: 24445167
Abstract
The physiological basis for musical hallucinations (MH) is not understood. One obstacle to understanding has been the lack of a method to manipulate the intensity of hallucination during the course of experiment. Residual inhibition, transient suppression of a phantom percept after the offset of a masking stimulus, has been used in the study of tinnitus. We report here a human subject whose MH were residually inhibited by short periods of music. Magnetoencephalography (MEG) allowed us to examine variation in the underlying oscillatory brain activity in different states. Source-space analysis capable of single-subject inference defined left-lateralised power increases, associated with stronger hallucinations, in the gamma band in left anterior superior temporal gyrus, and in the beta band in motor cortex and posteromedial cortex. The data indicate that these areas form a crucial network in the generation of MH, and are consistent with a model in which MH are generated by persistent reciprocal communication in a predictive coding hierarchy. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.
Details
- Title: Subtitle
- A brain basis for musical hallucinations
- Creators
- Sukhbinder Kumar - Newcastle UniversityWilliam Sedley - Newcastle UniversityGareth R. Barnes - Wellcome Centre for Human NeuroimagingSundeep Teki - Wellcome Centre for Human NeuroimagingKarl J. Friston - Wellcome Centre for Human NeuroimagingTimothy D. Griffiths - Wellcome Centre for Human Neuroimaging
- Resource Type
- Journal article
- Publication Details
- Cortex, Vol.52(1), pp.86-97
- DOI
- 10.1016/j.cortex.2013.12.002
- PMID
- 24445167
- PMCID
- PMC3969291
- NLM abbreviation
- Cortex
- ISSN
- 0010-9452
- eISSN
- 1973-8102
- Publisher
- Elsevier
- Number of pages
- 12
- Grant note
- WT091681MA / Wellcome Trust; European Commission MR/J011207/1 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) ACF-2009-01-006 / National Institute for Health Research; National Institute for Health Research (NIHR) MR/J011207/1 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission
- Language
- English
- Date published
- 03/01/2014
- Academic Unit
- Psychological and Brain Sciences; Neurosurgery
- Record Identifier
- 9984303908602771
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