Journal article
A brief period of sleep deprivation causes spine loss in the dentate gyrus of mice
Neurobiology of learning and memory, Vol.160, pp.83-90
04/2019
DOI: 10.1016/j.nlm.2018.03.018
PMCID: PMC6420875
PMID: 29588221
Abstract
•A short period of sleep deprivation reduces spine density in the dentate gyrus of the hippocampus.•Sleep deprivation has the most prominent effect on branched spines in the dentate gyrus.•The inferior blade of the dentate gyrus is more vulnerable to sleep loss than the superior blade.
Sleep and sleep loss have a profound impact on hippocampal function, leading to memory impairments. Modifications in the strength of synaptic connections directly influences neuronal communication, which is vital for normal brain function, as well as the processing and storage of information. In a recently published study, we found that as little as five hours of sleep deprivation impaired hippocampus-dependent memory consolidation, which was accompanied by a reduction in dendritic spine numbers in hippocampal area CA1. Surprisingly, loss of sleep did not alter the spine density of CA3 neurons. Although sleep deprivation has been reported to affect the function of the dentate gyrus, it is unclear whether a brief period of sleep deprivation impacts spine density in this region. Here, we investigated the impact of a brief period of sleep deprivation on dendritic structure in the dentate gyrus of the dorsal hippocampus. We found that five hours of sleep loss reduces spine density in the dentate gyrus with a prominent effect on branched spines. Interestingly, the inferior blade of the dentate gyrus seems to be more vulnerable in terms of spine loss than the superior blade. This decrease in spine density predominantly in the inferior blade of the dentate gyrus may contribute to the memory deficits observed after sleep loss, as structural reorganization of synaptic networks in this subregion is fundamental for cognitive processes.
Details
- Title: Subtitle
- A brief period of sleep deprivation causes spine loss in the dentate gyrus of mice
- Creators
- Frank Raven - Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, The NetherlandsPeter Meerlo - Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, The NetherlandsEddy A Van der Zee - Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, The NetherlandsTed Abel - Department of Molecular Physiology and Biophysics, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, USARobbert Havekes - Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, The Netherlands
- Resource Type
- Journal article
- Publication Details
- Neurobiology of learning and memory, Vol.160, pp.83-90
- DOI
- 10.1016/j.nlm.2018.03.018
- PMID
- 29588221
- PMCID
- PMC6420875
- NLM abbreviation
- Neurobiol Learn Mem
- ISSN
- 1074-7427
- eISSN
- 1095-9564
- Publisher
- Elsevier Inc
- Grant note
- name: Human Frontiers Science Program Organization, award: RGY0063/2017
- Language
- English
- Date published
- 04/2019
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984070679602771
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