A case-control comparison of the clinical characteristics of glaucoma and ocular hypertensive patients with and without the myocilin Gln368Stop mutation

Thomas A Graul; Young H Kwon; M Bridget Zimmerman; Chang-sik Kim; Val C Sheffield; Edwin M Stone; Wallace L M Alward

doi:10.1016/S0002-9394(02)01754-3

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A case-control comparison of the clinical characteristics of glaucoma and ocular hypertensive patients with and without the myocilin Gln368Stop mutation

Journal article

Peer reviewed

A case-control comparison of the clinical characteristics of glaucoma and ocular hypertensive patients with and without the myocilin Gln368Stop mutation

Thomas A Graul, Young H Kwon, M Bridget Zimmerman, Chang-sik Kim, Val C Sheffield, Edwin M Stone and Wallace L M Alward

American journal of ophthalmology, Vol.134(6), pp.884-890

12/2002

DOI: 10.1016/S0002-9394(02)01754-3

PMID: 12470758

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Abstract

To determine whether primary open-angle glaucoma (POAG) and ocular hypertensive (OHT) patients who harbor the myocilin Gln368Stop mutation differ in phenotype or clinical course from patients without the mutation. Case-control study. A retrospective case-control study compared all known POAG patients (n = 18) and OHT patients (n = 4) harboring the Gln368Stop mutation evaluated by the University of Iowa Glaucoma Service with control patients from the same population. Patients and control subjects were matched for diagnosis, age, sex, and race and were compared for phenotype and clinical course. Mean age of disease onset and mean peak intraocular pressures (IOPs) of cases were similar to those reported by other studies. There was no statistically significant difference between cases and controls for the following variables: age at onset, peak intraocular pressure, Snellen visual acuity, number of medications, Humphrey visual field (HVF) mean deviation, HVF pattern deviation, number of filtering surgeries performed, time intervals from diagnosis to argon laser trabeculoplasty (ALT), diagnosis to first filtering surgery, ALT to first filtering surgery, and percent change in IOP after ALT and after first filtering surgery. There is no statistically significant difference between the onset and clinical course of POAG and OHT caused by the Gln368Stop mutation and POAG and OHT not associated with the mutation.

Mutation

Cytoskeletal Proteins

Glycoproteins - genetics

Codon, Terminator - genetics

Glaucoma, Open-Angle - genetics

Intraocular Pressure

Ocular Hypertension - pathology

Humans

Middle Aged

Glaucoma, Open-Angle - pathology

Male

Visual Acuity

Case-Control Studies

Ocular Hypertension - genetics

Visual Fields

Age of Onset

Aged, 80 and over

Adult

Female

Aged

Retrospective Studies

Eye Proteins - genetics

Details

Title: Subtitle: A case-control comparison of the clinical characteristics of glaucoma and ocular hypertensive patients with and without the myocilin Gln368Stop mutation
Creators: Thomas A Graul - Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City 52242, USA
Young H Kwon
M Bridget Zimmerman
Chang-sik Kim - University of Iowa
Val C Sheffield
Edwin M Stone
Wallace L M Alward
Resource Type: Journal article
Publication Details: American journal of ophthalmology, Vol.134(6), pp.884-890
DOI: 10.1016/S0002-9394(02)01754-3
PMID: 12470758
NLM abbreviation: Am J Ophthalmol
ISSN: 0002-9394
eISSN: 1879-1891
Publisher: United States
Grant note: EY-10564 / NEI NIH HHS
Language: English
Date published: 12/2002
Academic Unit: Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Biostatistics; Medical Genetics and Genomics; Ophthalmology and Visual Sciences
Record Identifier: 9983980390002771

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