A case-control study of tobacco use and other non-occupational risk factors for lymphoma subtypes defined by t(14; 18) translocations and bcl-2 expression

Cindy M Chang; Jane C Schroeder; Andrew F Olshan; Cherie H Dunphy; Wen-Yi Huang; Ralph S Baric; Kathleen Conway; James R Cerhan; Charles F Lynch; Nathaniel Rothman; Kenneth P Cantor; Aaron Blair

doi:10.1007/s10552-010-9531-8

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A case-control study of tobacco use and other non-occupational risk factors for lymphoma subtypes defined by t(14; 18) translocations and bcl-2 expression

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A case-control study of tobacco use and other non-occupational risk factors for lymphoma subtypes defined by t(14; 18) translocations and bcl-2 expression

Cindy M Chang, Jane C Schroeder, Andrew F Olshan, Cherie H Dunphy, Wen-Yi Huang, Ralph S Baric, Kathleen Conway, James R Cerhan, Charles F Lynch, Nathaniel Rothman, …

Cancer causes & control, Vol.21(7), pp.1147-1154

07/2010

DOI: 10.1007/s10552-010-9531-8

PMCID: PMC3052629

PMID: 20232134

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Abstract

We re-evaluated reported associations between tobacco use and other factors and non-Hodgkin lymphoma (NHL) t(14; 18)-subtypes based on fluorescence in situ hybridization (FISH) assays believed to be more sensitive than polymerase chain reaction (PCR), previously used for detecting t(14; 18). Commercial FISH assays and bcl-2 immunostaining were performed on paraffin sections to determine t(14; 18) and bcl-2 case-subtypes. Polytomous logistic regression models estimated associations between NHL case-subtypes (versus 1,245 population-based controls) and tobacco use as well as other factors. Adjusting for age, state, and proxy status, t(14; 18)-negative NHL was associated with any tobacco use (vs. no tobacco use, OR = 1.9, 95% CI = 1.0-3.5), including current smoking (vs. no cigarette use, OR = 1.9, 95% CI = 1.1-3.2). Tobacco exposures were not clearly associated with t(14; 18)-positive NHL or bcl-2 case-subtypes. Hair-dye use and family history of a hemolymphatic cancer were associated with t(14; 18)-negative NHL, but the number of exposed cases was small. The association between t(14; 18)-negative NHL and cigarette smoking was unexpected given previous evidence of associations between smoking and follicular lymphoma (which is largely t(14; 18)-positive). Future studies characterizing additional molecular characteristics of t(14; 18)-negative NHL may help determine whether the association with smoking may have been causal versus an artifact of chance or bias.

Immunohistochemistry

Humans

Middle Aged

Risk Factors

In Situ Hybridization, Fluorescence

Logistic Models

Male

Lymphoma, Non-Hodgkin - genetics

Lymphoma, Non-Hodgkin - epidemiology

Case-Control Studies

Incidence

Minnesota - epidemiology

Chromosomes, Human, Pair 18

Lymphoma, Non-Hodgkin - metabolism

Proto-Oncogene Proteins c-bcl-2 - analysis

Adult

Chromosomes, Human, Pair 14

Iowa - epidemiology

Smoking

Translocation, Genetic - genetics

Details

Title: Subtitle: A case-control study of tobacco use and other non-occupational risk factors for lymphoma subtypes defined by t(14; 18) translocations and bcl-2 expression
Creators: Cindy M Chang - Infections and Immunoepidemiology Branch, National Cancer Institute, Rockville, MD, USA. changcm@mail.nih.gov
Jane C Schroeder
Andrew F Olshan
Cherie H Dunphy
Wen-Yi Huang
Ralph S Baric
Kathleen Conway
James R Cerhan
Charles F Lynch
Nathaniel Rothman
Kenneth P Cantor
Aaron Blair
Resource Type: Journal article
Publication Details: Cancer causes & control, Vol.21(7), pp.1147-1154
DOI: 10.1007/s10552-010-9531-8
PMID: 20232134
PMCID: PMC3052629
NLM abbreviation: Cancer Causes Control
ISSN: 0957-5243
eISSN: 1573-7225
Publisher: Netherlands
Grant note: P30ES10126 / NIEHS NIH HHS Z01 CP010119-12 / Intramural NIH HHS R24 HD050924 / NICHD NIH HHS R03 CA71617-01 / NCI NIH HHS P30 ES010126 / NIEHS NIH HHS
Language: English
Date published: 07/2010
Academic Unit: Epidemiology
Record Identifier: 9983996078402771

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