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A case of POEMS syndrome whose diagnostic clues were nerve conduction studies and serum immunofixation electrophoresis
Journal article   Open access

A case of POEMS syndrome whose diagnostic clues were nerve conduction studies and serum immunofixation electrophoresis

Ryo Tokimura, Ryo Hara, Akatsuki Kubota, Hiroyuki Ishiura, Satoshi Kodama, Yuichiro Shirota, Masashi Hamada and Tatsushi Toda
Japanese Journal of Clinical Neurophysiology, Vol.51(6), pp.651-657
12/01/2023
DOI: 10.11422/jscn.51.651
url
https://doi.org/10.11422/jscn.51.651View
Published (Version of record) Open Access

Abstract

A 59-year-old man presented with progressive lower-limb weakness and abnormal lower limb sensation over 4 months. Nerve conduction studies showed ulnar nerve demyelination in the forearm of the and severe neuropathy in the lower extremities. Serum protein electrophoresis was unremarkable, but serum immunofixation electrophoresis revealed IgA-lambda gammopathy, leading to the diagnosis of POEMS syndrome. Characteristic neurophysiological findings should prompt immunofixation electrophoresis to diagnose POEMS syndrome.
immunofixation electrophoresis M-protein nerve conduction studies POEMS syndrome polyneuropathy

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