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A case report and focused literature review of d‐penicillamine and severe neutropenia: A serious toxicity from a seldom‐used drug
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A case report and focused literature review of d‐penicillamine and severe neutropenia: A serious toxicity from a seldom‐used drug

Stuart K Pitman, Tony Huynh, Thorarinn A Bjarnason, Josiah An and Karen A Malkhasyan
Clinical Case Reports, Vol.7(5), pp.990-994
04/01/2019
DOI: 10.1002/ccr3.2125
PMCID: PMC6509885
PMID: 31110732
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Published (Version of record)CC BY-NC-ND V4.0 Open Access
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https://doi.org/10.1002/ccr3.2125View
Published (Version of record) Open Access

Abstract

Key Clinical Message Prescribing d‐penicillamine for Wilson's disease must be accompanied by vigilant monitoring, including a complete blood cell count with differential. For most, this should occur once or twice weekly during the first month of therapy and during periods of dose escalation, then every two weeks for six additional months, then monthly.
penicillamine neutropenia Wilson's disease Case Report Case Reports OAFund

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