Journal article
A chemical shift encoding (CSE) approach for spectral selection in fluorine-19 MRI
Magnetic resonance in medicine, Vol.79(4), pp.2183-2189
04/01/2018
DOI: 10.1002/mrm.26874
PMCID: PMC5811371
PMID: 28833448
Abstract
PurposeTo develop a chemical shift encoding (CSE) approach for fluorine-19 MRI of perfluorocarbons in the presence of multiple known fluorinated chemical species.
Theory and MethodsA multi-echo CSE technique is applied for spectral separation of the perfluorocarbon perfluoro-15-crown-5-ether (PFCE) and isoflurane (ISO) based on their chemical shifts at 4.7T. Cramer-Rao lower bound analysis is used to identify echo combinations with optimal signal-to-noise performance. Signal contributions are fit with a multispectral fluorine signal model using a non-linear least squares estimation reconstruction directly from k-space data. This CSE approach is tested in fluorine-19 phantoms and in a mouse with a 2D and 3D spoiled gradient-echo acquisition using multiple echo times determined from Cramer-Rao lower bound analysis.
ResultsCramer-Rao lower bound analysis for PFCE and ISO separation shows signal-to-noise performance is maximized with a 0.33 ms echo separation. A linear behavior (R-2=0.987) between PFCE signal and known relative PFCE volume is observed in CSE reconstructed images using a mixed PFCE/ISO phantom. Effective spatial and spectral separation of PFCE and ISO is shown in phantoms and in vivo.
ConclusionFeasibility of a gradient-echo CSE acquisition and image reconstruction approach with optimized noise performance is demonstrated through fluorine-19 MRI of PFCE with effective removal of ISO signal contributions. Magn Reson Med 79:2183-2189, 2018. (c) 2017 International Society for Magnetic Resonance in Medicine.
Details
- Title: Subtitle
- A chemical shift encoding (CSE) approach for spectral selection in fluorine-19 MRI
- Creators
- Kai D. Ludwig - University of Wisconsin–MadisonDiego Hernando - Medical PhysicsUniversity of WisconsinMadison Wisconsin USANathan T. Roberts - RadiologyUniversity of WisconsinMadison Wisconsin USARuud B. van Heeswijk - University of LausanneSean B. Fain - Medical PhysicsUniversity of WisconsinMadison Wisconsin USA
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.79(4), pp.2183-2189
- DOI
- 10.1002/mrm.26874
- PMID
- 28833448
- PMCID
- PMC5811371
- NLM abbreviation
- Magn Reson Med
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Publisher
- Wiley
- Number of pages
- 7
- Grant note
- UL1TR000427; TL1TR000429 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 133-AAB3113 / Hyundai Hope On Wheels University of Wisconsin Institute for Clinical and Translation Research (UW ICTR) T32CA009206 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) PZ00P3-154719 / Swiss National Science Foundation; Swiss National Science Foundation (SNSF); European Commission GE Healthcare; General Electric TL1TR000429 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) R01HL126771 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 04/01/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984274957202771
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