Journal article
A clinical trial evaluating pharmacist-guided self-management of hypertension among veterans with CKD, rationale and study design
Contemporary clinical trials, Vol.154, 107950
07/2025
DOI: 10.1016/j.cct.2025.107950
PMCID: PMC12702138
PMID: 40360073
Abstract
Chronic kidney disease (CKD) associates with high morbidity and mortality due to CKD progression and cardiovascular disease (CVD). Blood pressure (BP) lowering reduces the risk of CVD and CKD progression. Despite the large number of BP medications available, a significant proportion of patients with CKD have BP above the goal. The current practice involves licensed providers performing medication titrations to achieve BP goals and is associated with limited patient engagement. Here, we evaluate the effectiveness of pharmacist-guided patient-driven titration of BP medications in CKD.
Randomized clinical trial.
One hundred and sixty Veterans with uncontrolled hypertension and either stage 2 CKD with albuminuria or stage 3 or 4 CKD are recruited from the Iowa City VA Healthcare system.
Subjects are randomized to the pharmacist self-guided management arm or the self-monitoring arm for 12 months.
This is a mixed methods study. The primary outcome is change in standardized office systolic BP at 12 months. Secondary outcomes include change in standardized office diastolic BP, change in home systolic and diastolic BPs, change in conventional office systolic and diastolic BPs, and emergency room visits for uncontrolled hypertension or hypertensive emergency. The study team will conduct semi-structured interviews to evaluate the acceptability and the adherence to the self-management approach to Veterans and to assess potential barriers and facilitators to implementation of the self-management approach.
NCT05546099.
Details
- Title: Subtitle
- A clinical trial evaluating pharmacist-guided self-management of hypertension among veterans with CKD, rationale and study design
- Creators
- Mary Good - Center for Access and Delivery Research and Evaluation, Iowa City VA Health Care Center, Iowa City, IA, United States of AmericaRachael Hoskins - College of Pharmacy, University of Iowa, Iowa City, IA, United States of AmericaBrian C LundPatrick Ten Eyck - Institue for Clinical and Translational Science, Iowa City, IA, United States of AmericaBradley Dixon - Iowa City VA Health Care Center, Iowa City, IA, United States of AmericaJordana Cohen - University of PennsylvaniaHeather Schacht ReisingerKorey KenneltyDiana Jalal
- Resource Type
- Journal article
- Publication Details
- Contemporary clinical trials, Vol.154, 107950
- DOI
- 10.1016/j.cct.2025.107950
- PMID
- 40360073
- PMCID
- PMC12702138
- NLM abbreviation
- Contemp Clin Trials
- ISSN
- 1551-7144
- eISSN
- 1559-2030
- Publisher
- ELSEVIER SCIENCE INC
- Grant note
- VHA Health Services Research Grant: HX-22-001, UM1TR004403
VHA Health Services Research Grant HX-22-001 (Jalal) , UM1TR004403 (Ten Eyck) .
- Language
- English
- Electronic publication date
- 05/11/2025
- Date published
- 07/2025
- Academic Unit
- Anthropology; Epidemiology; Biostatistics; Family and Community Medicine; Pharmacy Practice and Science; Center for Social Science Innovation; Injury Prevention Research Center; Nephrology; Internal Medicine; Design Biostat and Ethics
- Record Identifier
- 9984822965902771
Metrics
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