A clock gene, period, plays a key role in long-term memory formation in Drosophila

Takaomi Sakai; Takuya Tamura; Toshihiro Kitamoto; Yoshiaki Kidokoro

doi:10.1073/pnas.0401472101

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A clock gene, period, plays a key role in long-term memory formation in Drosophila

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A clock gene, period, plays a key role in long-term memory formation in Drosophila

Takaomi Sakai, Takuya Tamura, Toshihiro Kitamoto and Yoshiaki Kidokoro

Proceedings of the National Academy of Sciences - PNAS, Vol.101(45), pp.16058-16063

11/09/2004

DOI: 10.1073/pnas.0401472101

PMCID: PMC528738

PMID: 15522971

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Abstract

The cAMP-responsive transcription factor, CREB, is required for formation of long-term memory (LTM) in Drosophila melanogaster and regulates transcription of a circadian clock gene, period ( per ). Involvement of CREB both in LTM and circadian rhythm raises the possibility that per also plays a role in LTM. Assaying the experience-dependent courtship inhibition in male flies as a measure for LTM, we show here that per mutants are defective in LTM formation. This defect was rescued by induction of a wild-type per transgene in a per -null mutant, and overexpression of per enhanced LTM formation in the wild-type background. Furthermore, we found that synaptic transmission through per -expressing cells is most likely to be required during retrieval of LTM. In contrast, mutations in other clock genes ( timeless , dClock , and cycle ) did not affect LTM formation. Thus, independent of the core oscillator of circadian clock, per plays a key role in LTM formation.

Biological Sciences

Details

Title: Subtitle: A clock gene, period, plays a key role in long-term memory formation in Drosophila
Creators: Takaomi Sakai - Gunma University Graduate School of Medicine, 3-39-22, Showa-Machi, Maebashi 371-8511, Japan; and
Takuya Tamura - Gunma University Graduate School of Medicine, 3-39-22, Showa-Machi, Maebashi 371-8511, Japan; and
Toshihiro Kitamoto - Gunma University Graduate School of Medicine, 3-39-22, Showa-Machi, Maebashi 371-8511, Japan; and
Yoshiaki Kidokoro - Gunma University Graduate School of Medicine, 3-39-22, Showa-Machi, Maebashi 371-8511, Japan; and
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.101(45), pp.16058-16063
DOI: 10.1073/pnas.0401472101
PMID: 15522971
PMCID: PMC528738
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: National Academy of Sciences
Language: English
Date published: 11/09/2004
Academic Unit: Iowa Neuroscience Institute; Anesthesia; Neuroscience and Pharmacology
Record Identifier: 9984006488702771

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