A clock gene, period, plays a key role in long-term memory formation in Drosophila

Takaomi Sakai; Takuya Tamura; Toshihiro Kitamoto; Yoshiaki Kidokoro

doi:10.1073/pnas.0401472101

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A clock gene, period, plays a key role in long-term memory formation in Drosophila

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A clock gene, period, plays a key role in long-term memory formation in Drosophila

Takaomi Sakai, Takuya Tamura, Toshihiro Kitamoto and Yoshiaki Kidokoro

Proceedings of the National Academy of Sciences - PNAS, Vol.101(45), pp.16058-16063

11/09/2004

DOI: 10.1073/pnas.0401472101

PMCID: PMC528738

PMID: 15522971

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Abstract

The cAMP-responsive transcription factor, CREB, is required for formation of long-term memory (LTM) in Drosophila melanogaster and regulates transcription of a circadian clock gene, period (per). Involvement of CREB both in LTM and circadian rhythm raises the possibility that per also plays a role in LTM. Assaying the experience-dependent courtship inhibition in male flies as a measure for LTM, we show here that per mutants are defective in LTM formation. This defect was rescued by induction of a wild-type per transgene in a per-null mutant, and overexpression of per enhanced LTM formation in the wild-type background. Furthermore, we found that synaptic transmission through per-expressing cells is most likely to be required during retrieval of LTM. In contrast, mutations in other clock genes (timeless, dClock, and cycle) did not affect LTM formation. Thus, independent of the core oscillator of circadian clock, per plays a key role in LTM formation.

Biological Sciences

Details

Title: Subtitle: A clock gene, period, plays a key role in long-term memory formation in Drosophila
Creators: Takaomi Sakai - Gunma University Graduate School of Medicine, 3-39-22, Showa-Machi, Maebashi 371-8511, Japan; and
Takuya Tamura - Gunma University Graduate School of Medicine, 3-39-22, Showa-Machi, Maebashi 371-8511, Japan; and
Toshihiro Kitamoto - Gunma University Graduate School of Medicine, 3-39-22, Showa-Machi, Maebashi 371-8511, Japan; and
Yoshiaki Kidokoro - Gunma University Graduate School of Medicine, 3-39-22, Showa-Machi, Maebashi 371-8511, Japan; and
Resource Type: Journal article
Publication Details: Proceedings of the National Academy of Sciences - PNAS, Vol.101(45), pp.16058-16063
DOI: 10.1073/pnas.0401472101
PMID: 15522971
PMCID: PMC528738
NLM abbreviation: Proc Natl Acad Sci U S A
ISSN: 0027-8424
eISSN: 1091-6490
Publisher: National Academy of Sciences
Language: English
Date published: 11/09/2004
Academic Unit: Iowa Neuroscience Institute; Anesthesia; Neuroscience and Pharmacology
Record Identifier: 9984006488702771

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