Journal article
A closed-chest catheter technique for producing aortic regurgitation in dogs
Journal of applied physiology (1948), Vol.33(5), pp.693-695
11/1972
DOI: 10.1152/jappl.1972.33.5.693
PMID: 4635936
Abstract
A simple method for producing hemodynamically significant aortic regurgitation in a closed-chest dog has been developed. It is particularly applicable for studies requiring serial observations of chronic pathophysiological mechanisms in the chronically instrumented conscious animal. A needle-tipped, spring-loaded wire is introduced through a catheter inserted in a carotid artery and used to puncture the aortic valve. This tear is then enlarged with a Fogarty embolectomy catheter. By use of this technique, angiographically severe aortic regurgitation was produced in five anesthetized dogs. Acutely, mean aortic diastolic pressure fell from 84 to 55 mm Hg causing an increase in pulse pressure from 44 to 74 mm Hg. End-diastolic volume, measured immediately before and after aortic regurgitation with chronically implanted endocardial markers, increased from 51 to 62 ml (P < 0.02), while end-systolic volume rose from 31 to 34 ml (P < 0.05).
Details
- Title: Subtitle
- A closed-chest catheter technique for producing aortic regurgitation in dogs
- Creators
- Stephen J LeshinLawrence D Horwitz
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1948), Vol.33(5), pp.693-695
- DOI
- 10.1152/jappl.1972.33.5.693
- PMID
- 4635936
- ISSN
- 0021-8987
- eISSN
- 2691-2473
- Language
- English
- Date published
- 11/1972
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656608302771
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