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A cluster randomized trial to evaluate physician/pharmacist collaboration to improve blood pressure control
Journal article   Open access   Peer reviewed

A cluster randomized trial to evaluate physician/pharmacist collaboration to improve blood pressure control

Barry L Carter, Karen B Farris, William R Doucette, George R Bergus, Arthur J Hartz, Jeffrey D Dawson and Elizabeth A Chrischilles
The journal of clinical hypertension (Greenwich, Conn.), Vol.10(4), pp.260-271
2008
DOI: 10.1111/j.1751-7176.2008.07434.x
PMID: 18401223
url
https://doi.org/10.1111/j.1751-7176.2008.07434.xView
Published (Version of record) Open Access

Abstract

This was a prospective, cluster randomized controlled trial in patients with uncontrolled hypertension aged 21 to 85 years (mean, 61 years). Pharmacists made recommendations to physicians for patients in the intervention clinics (n=101) but not patients in the control clinics (n=78). The mean adjusted difference in systolic blood pressure (BP) between the control and intervention groups was 8.7 mm Hg (95% confidence interval [CI], 4.4-12.9), while the difference in diastolic BP was 5.4 mm Hg (CI, 2.8-8.0) at 9 months. The 24-hour BP levels showed similar effects, with a mean systolic BP level that was 8.8 mm Hg lower (CI, 5.0-12.6) and a mean diastolic BP level that was 4.6 mm Hg (CI, 2.4-6.8) lower in the intervention group. BP was controlled in 89.1% of patients in the intervention group and 52.9% in the control group (adjusted odds ratio, 8.9; CI, 3.8-20.7; P<.001). Physician/pharmacist collaboration achieved significantly better mean BP values and overall BP control rates, primarily by intensification of medication therapy and improving patient adherence.

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