Journal article
A combination of 5-fluorouracil and thymidine in advanced colorectal carcinoma
Cancer chemotherapy and pharmacology, Vol.13(3), pp.218-222
10/1984
DOI: 10.1007/BF00269033
PMID: 6488442
Abstract
Concurrent administration of thymidine (TdR) has been shown to increase the antitumor activity of 5-fluorouracil (5-FU) in various experimental models. The clinical response rate, side-effects, and toxicity of 5-FU und TdR were evaluated in 27 patients with advanced colorectal carcinomas. Each 6-day treatment course consisted of an IV loading dose of TdR (405 mg/kg, over 30 min), followed by continuous IV infusions of 5-FU (7.5 mg/kg per day for 5 days), and TdR (216 mg/kg per day for 6 days); courses were repeated every 4 weeks. The overall partial response rate was 4.5%, or 16.7% in patients with no prior 5-FU chemotherapy. Short-lived stable disease was seen at an overall rate of 27.3%, half of these patients with prior 5-FU chemotherapy. Myelotoxicity occurred in 64% of the patients, but this was dose-limiting in only 20%. Gastrointestinal and neurological symptoms were mild and infrequent. There was one case of treatment-related death due to sepsis secondary to leukopenia. It is concluded that the concurrent IV administration of 5-FU and TdR does not improve the response rate over that obtained with 5-FU alone. © 1984 Springer-Verlag.
Details
- Title: Subtitle
- A combination of 5-fluorouracil and thymidine in advanced colorectal carcinoma
- Creators
- Ahud Sternberg - Roswell Park Cancer InstituteNicholas J. Petrelli - Roswell Park Cancer InstituteJesse Au - Roswell Park Cancer InstituteYoucef Rustum - Roswell Park Cancer InstituteArnold Mittelman - Roswell Park Cancer InstitutePatrick Creaven - Roswell Park Cancer Institute
- Resource Type
- Journal article
- Publication Details
- Cancer chemotherapy and pharmacology, Vol.13(3), pp.218-222
- DOI
- 10.1007/BF00269033
- PMID
- 6488442
- ISSN
- 0344-5704
- eISSN
- 1432-0843
- Language
- English
- Date published
- 10/1984
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359944602771
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