A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force

Jan A Gorter; Erwin A van Vliet; Stefanie Dedeurwaerdere; Gordon F Buchanan; Daniel Friedman; Karin Borges; Heidi Grabenstatter; Katarzyna Lukasiuk; Helen E Scharfman; Astrid Nehlig

doi:10.1002/epi4.12261

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A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force

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A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force

Jan A Gorter, Erwin A van Vliet, Stefanie Dedeurwaerdere, Gordon F Buchanan, Daniel Friedman, Karin Borges, Heidi Grabenstatter, Katarzyna Lukasiuk, Helen E Scharfman and Astrid Nehlig

Epilepsia open, Vol.3(Suppl Suppl 1), pp.69-89

2018

DOI: 10.1002/epi4.12261

PMCID: PMC6210044

PMID: 30411072

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Abstract

The International League Against Epilepsy/American Epilepsy Society ( ILAE / AES ) Joint Translational Task Force created the TASK 3 working groups to create common data elements ( CDE s) for various aspects of preclinical epilepsy research studies, which could help improve standardization of experimental designs . This article concerns the parameters that can be measured to assess the physiologic condition of the animals that are used to study rodent models of epilepsy. Here we discuss CDE s for physiologic parameters measured in adult rats and mice such as general health status, temperature, cardiac and respiratory function, and blood constituents. We provide detailed CDE tables and case report forms ( CRF s), and with this companion manuscript we discuss the monitoring of different aspects of physiology of the animals. The CDE s, CRF s, and companion paper are available to all researchers, and their use will benefit the harmonization and comparability of translational preclinical epilepsy research. The ultimate hope is to facilitate the development of biomarkers and new treatments for epilepsy.

Epilepsy

Physiology

Common data elements

Supplement

Model

Preclinical

Rodent

Details

Title: Subtitle: A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force
Creators: Jan A Gorter - University of Amsterdam
Erwin A van Vliet - University of Amsterdam
Stefanie Dedeurwaerdere - UCB Pharma
Gordon F Buchanan - University of Iowa Carver College of Medicine
Daniel Friedman - NYU Langone Medical Center
Karin Borges - The University of Queensland
Heidi Grabenstatter - University of Colorado
Katarzyna Lukasiuk - Polish Academy of Sciences
Helen E Scharfman - The Nathan Kline Institute for Psychiatric Research and New York University Langone Medical Center
Astrid Nehlig - University of Paris Descartes
Resource Type: Journal article
Publication Details: Epilepsia open, Vol.3(Suppl Suppl 1), pp.69-89
DOI: 10.1002/epi4.12261
PMID: 30411072
PMCID: PMC6210044
NLM abbreviation: Epilepsia Open
ISSN: 2470-9239
eISSN: 2470-9239
Publisher: John Wiley and Sons Inc; Hoboken
Language: English
Date published: 2018
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984070129302771

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