Journal article
A comparative study of the effects of repetitive paired transcranial magnetic stimulation on motor cortical excitability
Journal of neuroscience methods, Vol.165(2), pp.265-269
09/30/2007
DOI: 10.1016/j.jneumeth.2007.06.002
PMID: 17628691
Abstract
Various methods of application of repetitive transcranial magnetic stimulation (TMS) have been evaluated for their potential capacity to alter motor cortical excitability. Initial research suggests that the repetitive application of paired TMS pulses (repetitive paired pulse TMS (rppTMS)) may have greater effects on cortical excitability, perhaps through the facilitation of I-wave interaction. We aimed to compare the post-train effects of 15
min trains of rppTMS to investigate the potential therapeutic application of this technique as well as to compare it to a standard high frequency repetitive TMS paradigm.
Ten normal subjects received three 15
min sessions of rppTMS, 5
Hz high frequency rTMS and sham TMS in randomised order. rppTMS consisted of a single train of 180 pulse pairs (0.2
Hz, 1.5
ms inter-stimulus interval, supra-threshold intensity) administered over 15
min. The rTMS condition involved 750 pulses provided in 5
s 5
Hz trains with a 25
s inter-train interval at 90% of the RMT. Motor evoked potential size and cortical silent period duration were assessed before and after each session.
There were no significant changes in cortical excitability produced by any of the stimulation conditions. Five hertz rTMS produced an increase in cortical silent period duration (
p
=
0.004) which was not affected by rppTMS.
Fifteen minutes trains of 1.5
ms rppTMS do not substantially increase post train cortical excitability. Repetitive brief trains of 5
Hz rTMS also do not alter excitability but appear to effect cortical inhibition.
Details
- Title: Subtitle
- A comparative study of the effects of repetitive paired transcranial magnetic stimulation on motor cortical excitability
- Creators
- Paul B. Fitzgerald - Monash UniversitySarah Fountain - Monash UniversityKate Hoy - Monash UniversityJerome Maller - Monash UniversityPeter Enticott - Monash UniversityRobin Laycock - Monash UniversityDaniel Upton - Monash UniversityZafiris J. Daskalakis - Centre for Addiction and Mental Health
- Resource Type
- Journal article
- Publication Details
- Journal of neuroscience methods, Vol.165(2), pp.265-269
- DOI
- 10.1016/j.jneumeth.2007.06.002
- PMID
- 17628691
- NLM abbreviation
- J Neurosci Methods
- ISSN
- 0165-0270
- eISSN
- 1872-678X
- Publisher
- Elsevier B.V
- Number of pages
- 5
- Language
- English
- Date published
- 09/30/2007
- Academic Unit
- Radiology
- Record Identifier
- 9984848424802771
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