A comparison of approaches to the statistical analysis of [15O]H2O PET cognitive activation studies

S Arndt; T Cizadlo; N C Andreasen; G Zeien; G Harris; D S O'Leary; G L Watkins; L L Ponto; R D Hichwa

doi:10.1176/jnp.7.2.155

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A comparison of approaches to the statistical analysis of [15O]H2O PET cognitive activation studies

Journal article

Peer reviewed

A comparison of approaches to the statistical analysis of [15O]H2O PET cognitive activation studies

S Arndt, T Cizadlo, N C Andreasen, G Zeien, G Harris, D S O'Leary, G L Watkins, L L Ponto and R D Hichwa

The journal of neuropsychiatry and clinical neurosciences, Vol.7(2), pp.155-168

1995

DOI: 10.1176/jnp.7.2.155

PMID: 7626958

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Abstract

This study compares two of the most widely used statistical techniques for analyzing data obtained from [15O]H2O PET studies of brain function. The Friston method (SPM94) and the Worsley (Montreal) method were applied to a single data set of 33 subjects who were studied in a paradigm designed to evaluate memory for word lists. Neither of these methods emerged as either strikingly different or strikingly preferable, although the occasional differences may be important in some experiments. In general, the two methods were found to produce similar results in identifying brain regions active during long-term memory: frontal, parietal, cingulate, and cerebellar. Underlying assumptions of the two methods, as well as their strengths and weaknesses, are discussed.

Software

Brain - diagnostic imaging

Data Interpretation, Statistical

Oxygen Radioisotopes

Humans

Reference Values

Verbal Learning - physiology

Retention (Psychology) - physiology

Brain - physiology

Frontal Lobe - physiology

Attention - physiology

Frontal Lobe - diagnostic imaging

Arousal - physiology

Tomography, Emission-Computed - statistics & numerical data

Image Processing, Computer-Assisted

Numerical Analysis, Computer-Assisted

Dominance, Cerebral

Mental Recall - physiology

Brain Mapping

Long-Term Potentiation - physiology

Details

Title: Subtitle: A comparison of approaches to the statistical analysis of [15O]H2O PET cognitive activation studies
Creators: S Arndt - Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City 52242-1057, USA
T Cizadlo
N C Andreasen
G Zeien
G Harris
D S O'Leary
G L Watkins
L L Ponto
R D Hichwa
Resource Type: Journal article
Publication Details: The journal of neuropsychiatry and clinical neurosciences, Vol.7(2), pp.155-168
DOI: 10.1176/jnp.7.2.155
PMID: 7626958
NLM abbreviation: J Neuropsychiatry Clin Neurosci
ISSN: 0895-0172
eISSN: 1545-7222
Publisher: United States
Grant note: MH31593 / NIMH NIH HHS MH40856 / NIMH NIH HHS MHCRC 43271 / NIMH NIH HHS
Language: English
Date published: 1995
Academic Unit: Radiology; Psychiatry; Research Administration; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Biostatistics; Physics and Astronomy; Radiation Oncology; Nursing; Injury Prevention Research Center
Record Identifier: 9984003937802771

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