A comparison of associations of body mass index and dual-energy x-ray absorptiometry measured percentage fat and total fat with global serum metabolites in young women

Joanne F Dorgan; Alice S Ryan; Erin S LeBlanc; Linda Van Horn; Laurence S Magder; Linda G Snetselaar; Yuji Zhang; Cher M Dallal; Seungyoun Jung; John A Shepherd

doi:10.1002/oby.23619

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A comparison of associations of body mass index and dual-energy x-ray absorptiometry measured percentage fat and total fat with global serum metabolites in young women

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A comparison of associations of body mass index and dual-energy x-ray absorptiometry measured percentage fat and total fat with global serum metabolites in young women

Joanne F Dorgan, Alice S Ryan, Erin S LeBlanc, Linda Van Horn, Laurence S Magder, Linda G Snetselaar, Yuji Zhang, Cher M Dallal, Seungyoun Jung and John A Shepherd

Obesity (Silver Spring, Md.), Vol.31(2), pp.525-536

01/15/2023

DOI: 10.1002/oby.23619

PMCID: PMC9937438

PMID: 36642094

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https://pmc.ncbi.nlm.nih.gov/articles/PMC9937438/pdf/nihms-1842442.pdfView

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Abstract

Body mass index (BMI) does not directly measure adiposity, whereas dual-energy x-ray absorptiometry (DXA) provides valid direct estimates of adiposity. Therefore, this study evaluated usefulness of BMI as a measure of adiposity in serum metabolomics studies. A cross-sectional analysis was conducted of 202 women aged 25 to 29 years in the Dietary Intervention Study in Children Follow-Up Study. Heights and weights were measured, and body composition was quantified using clinical DXA protocols. Serum metabolomic profiling was performed by liquid chromatography-tandem mass spectrometry. Partial correlations of BMI, percentage fat (%FAT), and total fat (TOTFAT) with log transformed serum metabolites were calculated. There was significant overlap in the 93 metabolites that correlated with BMI, %FAT, and/or TOTFAT; 9 differently correlated with BMI and %FAT, whereas 15 differently correlated with BMI and TOTFAT. Even for these metabolites, absolute differences were modest. Metabolite set enrichment analysis identified diacylglycerol and sphingolipid metabolism as overrepresented among metabolites significantly correlated with all three measures of adiposity. BMI can be a good proxy for DXA measured %FAT and TOTFAT in descriptive metabolomic studies of healthy, young White women. Larger studies in more diverse populations are needed to endorse more generalized conclusions.

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Title: Subtitle: A comparison of associations of body mass index and dual-energy x-ray absorptiometry measured percentage fat and total fat with global serum metabolites in young women
Creators: Joanne F Dorgan - University of Maryland, Baltimore
Alice S Ryan - University of Maryland, Baltimore
Erin S LeBlanc - Kaiser Permanente Center for Health Research
Linda Van Horn - Northwestern University
Laurence S Magder - University of Maryland, Baltimore
Linda G Snetselaar - University of Iowa
Yuji Zhang - University of Maryland, Baltimore
Cher M Dallal - Department of Epidemiology and Biostatistics, University of Maryland School of Public Health, College Park, Maryland, USA.
Seungyoun Jung - Ewha Womans University
John A Shepherd - University of Hawaiʻi at Mānoa
Resource Type: Journal article
Publication Details: Obesity (Silver Spring, Md.), Vol.31(2), pp.525-536
DOI: 10.1002/oby.23619
PMID: 36642094
PMCID: PMC9937438
NLM abbreviation: Obesity (Silver Spring)
ISSN: 1930-7381
eISSN: 1930-739X
Grant note: R01CA104670 / NIH HHS Maryland Cigarette Restitution Fund / Maryland Department of Health R01CA214783 / NIH HHS P30CA134274 / NIH HHS IK6 RX003977 / RRD VA
Language: English
Date published: 01/15/2023
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984360036102771

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