Journal article
A comparison of diabetic polyneuropathy in Type II diabetic BBZDR/Wor rats and in Type I diabetic BB/Wor rats
Diabetologia, Vol.43(6), pp.786-793
2000
DOI: 10.1007/s001250051376
PMID: 10907124
Abstract
Aims/hypothesis. To examine the functional, metabolic and structural abnormalities in peripheral nerve in the spontaneously Type II (non-insulin-dependent) diabetic BBZDR/Wor rat and compare these data with those in the Type I (insulin-dependent) diabetic BB/Wor rat.¶Methods. Animals were examined at 6 and 14 months of diabetes. Nerve conduction velocity was measured longitudinally. Nerve polyols were analysed using gas liquid chromatography and Na/K+-ATPase activity was measured enzymatically. Light and electron microscopic techniques were used for nerve morphometry.¶Results. Diabetic BBZDR/Wor rats showed a slowly progressive nerve conduction defect that reached 17 % (p < 0.01) at 14 months. There was a decrease in Na+/K+-ATPase of 35 % (p < 0.05). Structurally, there were mild myelinated fibre atrophy (p < 0.05), mild or absent changes of the node of Ranvier, but significant (p < 0.001) segmental demyelination and Wallerian degeneration. These findings point to a more severe nerve conduction defect, severe myelinated fibre atrophy and profound nodal changes in Type I spontaneously diabetic BB/Wor rats maintained at the same hyperglycaemic concentrations.¶Conclusion/interpretation. We conclude that other factors, beside hyperglycaemia, are involved in the pathogenesis of the more severe Type I diabetic neuropathy which possibly involve insulin and C-peptide deficiencies.
Details
- Title: Subtitle
- A comparison of diabetic polyneuropathy in Type II diabetic BBZDR/Wor rats and in Type I diabetic BB/Wor rats
- Creators
- A. A. F SIMA - Departments of Pathology and Neurology, Wayne State University, Detroit, Michigan, United StatesW ZHANG - Departments of Pathology and Neurology, Wayne State University, Detroit, Michigan, United StatesG XU - Wayne State UniversityK SUGIMOTO - Departments of Pathology and Neurology, Wayne State University, Detroit, Michigan, United StatesD GUBERSKI - Biomedical Research Models Inc., Worcester, Massachusetts, United StatesM. A YOREK - Department of Medicine, University of Iowa, Iowa City, Iowa, United States
- Resource Type
- Journal article
- Publication Details
- Diabetologia, Vol.43(6), pp.786-793
- Publisher
- Springer
- DOI
- 10.1007/s001250051376
- PMID
- 10907124
- ISSN
- 0012-186X
- eISSN
- 1432-0428
- Language
- English
- Date published
- 2000
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984094664302771
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