A comparison of heterotopic and intrauterine-only pregnancy outcomes after assisted reproductive technologies in the United States from 1999 to 2002

Heather B Clayton; Laura A Schieve; Herbert B Peterson; Denise J Jamieson; Meredith A Reynolds; Victoria C Wright

doi:10.1016/j.fertnstert.2006.06.037

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A comparison of heterotopic and intrauterine-only pregnancy outcomes after assisted reproductive technologies in the United States from 1999 to 2002

Journal article

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A comparison of heterotopic and intrauterine-only pregnancy outcomes after assisted reproductive technologies in the United States from 1999 to 2002

Heather B Clayton, Laura A Schieve, Herbert B Peterson, Denise J Jamieson, Meredith A Reynolds and Victoria C Wright

Fertility and sterility, Vol.87(2), pp.303-309

02/01/2007

DOI: 10.1016/j.fertnstert.2006.06.037

PMID: 17113092

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Abstract

Objective: To compare the risk for adverse outcomes of pregnancies between heterotopic (defined as a simultaneous intrauterine and ectopic pregnancy) and intrauterine-only pregnancies achieved through assisted reproductive technologies (ARTs). Design: Retrospective cohort study. Setting: ART centers in the United States. Patient(s): Patients were studied in terms of cycles reported to the population-based United States ART Registry, which included 207 heterotopic and 132,660 intrauterine-only pregnancies reported from 1999 to 2002. Intervention(s): None. Main outcome measure(s): Outcomes of heterotopic and intrauterine-only pregnancies and deliveries (spontaneous abortion, induced abortion, still birth, and live birth). Perinatal outcomes (preterm, low birth weight [LBW], preterm LBW, and term LBW) for live-birth deliveries were also assessed. Result(s): Heterotopic pregnancies were more likely to end in spontaneous (relative risk = 2.05; 95% confidence interval, 1.67-2.51) or induced (relative risk = 10.28, 95% confidence interval, 6.76-15.65) abortions than were intrauterine-only pregnancies. There was no significant difference in perinatal outcomes studied, regardless of adjustment for maternal age, infertility diagnosis, previous live births, and type of ART procedure. Conclusion(s): Heterotopic pregnancies were more likely to result in spontaneous or induced abortions than were intrauterine-only pregnancies. There was no difference in perinatal outcomes between heterotopic and intrauterine-only pregnancies progressing to live birth.

Biological and medical sciences

Diseases of mother, fetus and pregnancy

Gynecology. Andrology. Obstetrics

Medical sciences

Pregnancy. Fetus. Placenta

Details

Title: Subtitle: A comparison of heterotopic and intrauterine-only pregnancy outcomes after assisted reproductive technologies in the United States from 1999 to 2002
Creators: Heather B Clayton - National Center for Chronic Disease Prevention and Health Promotion
Laura A Schieve - National Center for Chronic Disease Prevention and Health Promotion
Herbert B Peterson - University of North Carolina at Chapel Hill
Denise J Jamieson - National Center for Chronic Disease Prevention and Health Promotion
Meredith A Reynolds - National Center for Chronic Disease Prevention and Health Promotion
Victoria C Wright - National Center for Chronic Disease Prevention and Health Promotion
Resource Type: Journal article
Publication Details: Fertility and sterility, Vol.87(2), pp.303-309
DOI: 10.1016/j.fertnstert.2006.06.037
PMID: 17113092
NLM abbreviation: Fertil Steril
ISSN: 0015-0282
eISSN: 1556-5653
Publisher: Elsevier Science
Language: English
Date published: 02/01/2007
Academic Unit: Obstetrics and Gynecology; VPMA - Administration
Record Identifier: 9984446268202771

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