Journal article
A comprehensive genetic linkage map of the human genome. NIH/CEPH Collaborative Mapping Group
Science (American Association for the Advancement of Science), Vol.258(5079), pp.67-86
10/02/1992
DOI: 10.1126/science.1439770
PMID: 1439770
Abstract
A genetic linkage map of the human genome was constructed that consists of 1416 loci, including 279 genes and expressed sequences. The loci are represented by 1676 polymorphic systems genotyped with the CEPH reference pedigree resource. A total of 339 microsatellite repeat markers assayed by PCR are contained within the map, and of the 351 markers with heterozygosities of at least 70%, 205 are microsatellites. Seven telomere loci define physical and genetic endpoints for 2q, 4p, 7q, 8p, 14q, 16p, and 16q, and in other cases distal markers on the maps have been localized to terminal cytogenetic bands. Therefore, at least 92% of the autosomal length of the genome and 95% of the X chromosome is estimated to be spanned by the map. Since the maps have relatively high marker density and numerous highly informative loci, they can be used to map disease phenotypes, even for those with limited pedigree resources. The baseline map provides a foundation for achieving continuity of clone-based physical maps and for the development of a truly integrated physical, genetic, and cytogenetic map of the human.
Details
- Title: Subtitle
- A comprehensive genetic linkage map of the human genome. NIH/CEPH Collaborative Mapping Group
- Creators
- NIH/CEPH Collaborative Mapping Group
- Contributors
- Jeffrey C Murray (Contributor) - University of Iowa, Dental Research
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.258(5079), pp.67-86
- DOI
- 10.1126/science.1439770
- PMID
- 1439770
- NLM abbreviation
- Science
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Language
- English
- Date published
- 10/02/1992
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
- Record Identifier
- 9984025585802771
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