Journal article
A comprehensive guide to antibody and T-cell responses in type 1 diabetes
Tissue antigens, Vol.62(5), pp.359-377
Received and accepted for publication 6 August 2003
11/2003
DOI: 10.1034/j.1399-0039.2003.00152.x
PMID: 14617043
Abstract
Type 1 diabetes (T1D) is an organ-specific autoimmune disease in which the insulin-producing beta cells in the pancreatic islets are selectively eliminated. T cells specific for beta-cell antigens are the mediators of this precise cellular destruction. However, antibodies to beta-cell proteins are also generated and may be used for predicting disease in at-risk populations. Over the past two decades, numerous beta-cell proteins and lipids have been implicated as autoantigens in patients or in non-obese diabetic (NOD) mice, a well-studied animal model of T1D. Here, we present a review of these antigens, accompanied by their T-cell epitopes, where known, and a discussion of our current understanding of why particular self-proteins become disease-inciting antigens. Although two dozen beta-cell antigens have been identified to date, few of these have been confirmed to be recognized by pathogenic T cells early in the disease process. Further identification and characterization of initiating beta-cell antigens targeted by pathogenic T cells should be a priority for future studies.
Details
- Title: Subtitle
- A comprehensive guide to antibody and T-cell responses in type 1 diabetes
- Creators
- S.M Lieberman - Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USAT.P DiLorenzo - Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
- Resource Type
- Journal article
- Publication Details
- Tissue antigens, Vol.62(5), pp.359-377
- Edition
- Received and accepted for publication 6 August 2003
- Publisher
- Munksgaard International Publishers
- DOI
- 10.1034/j.1399-0039.2003.00152.x
- PMID
- 14617043
- ISSN
- 0001-2815
- eISSN
- 1399-0039
- Number of pages
- 19
- Language
- English
- Date published
- 11/2003
- Academic Unit
- Stead Family Department of Pediatrics; Rheumatology, Allergy, and Immunology
- Record Identifier
- 9984093595402771
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