Journal article
A comprehensive human linkage map with centimorgan density. Cooperative Human Linkage Center (CHLC)
Science (American Association for the Advancement of Science), Vol.265(5181), pp.2049-2054
09/30/1994
DOI: 10.1126/science.8091227
PMID: 8091227
Abstract
In the last few years there have been rapid advances in developing genetic maps for humans, greatly enhancing our ability to localize and identify genes for inherited disorders. Through the collaborative efforts of three large groups generating microsatellite markers and the efforts of the 110 CEPH collaborators, a comprehensive human linkage map is presented here. It consists of 5840 loci, of which 970 are uniquely ordered, covering 4000 centimorgans on the sex-averaged map. Of these loci, 3617 are polymerase chain reaction-formatted short tandem repeat polymorphisms, and another 427 are genes. The map has markers at an average density of 0.7 centimorgan, providing a resource for ready transference to physical maps and achieving one of the first goals of the Human Genome Project--a comprehensive, high-density genetic map.
Details
- Title: Subtitle
- A comprehensive human linkage map with centimorgan density. Cooperative Human Linkage Center (CHLC)
- Creators
- Jeffery C Murray - Department of Pediatrics, University of Iowa, Iowa City 52245Kenneth H BuetowJames L WeberSusan LudwigsenTitia Scherpbier-HeddemaFrank ManionJohn QuillenVal C SheffieldSara SundenGeoffrey M DuykJean Weissenbach - Stanford University School of MedicineGabor GyapayColette DibJean MorrissetteG.Mark LathropAlain VignalRay White - University of UtahNorisada Matsunami - University of UtahSteven Gerken - University of UtahRoberta Mells - University of UtahHans Albertsen - University of UtahRosemarie Plaetke - University of UtahShannon OdelbergDavid Ward - Yale UniversityJean Dausset - Fondation Jean Dausset-CEPHDaniel M CohenHoward M Cann
- Resource Type
- Journal article
- Publication Details
- Science (American Association for the Advancement of Science), Vol.265(5181), pp.2049-2054
- DOI
- 10.1126/science.8091227
- PMID
- 8091227
- NLM abbreviation
- Science
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Publisher
- United States
- Language
- English
- Date published
- 09/30/1994
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Iowa Neuroscience Institute; Medical Genetics and Genomics; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research; Ophthalmology and Visual Sciences
- Record Identifier
- 9984025407202771
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