Journal article
A controlled magnetic resonance imaging study of corpus callosum thickness in schizophrenia
Biological psychiatry (1969), Vol.21(3), pp.274-282
1986
DOI: 10.1016/0006-3223(86)90048-X
PMID: 3947709
Abstract
Two previous postmortem studies reported an increased thickness of the corpus callosum in schizophrenic patients compared to psychiatric controls. We report an in vivo study of the corpus callosum in schizophrenic patients (
n = 38) and healthy controls (
n = 41) using magnetic resonance (MR) brain imaging. A significant increase in mean callosal thickness was found in the middle and anterior, but not the posterior, parts of the callosal body. However, when the patients and controls were compared by gender and handedness schizophrenic men were found not to differ from control men in callosal thickness, regardless of handedness, whereas schizophrenic women were found to have a highly significant increase in callosal middle and anterior thickness compared to control women The data suggest that increased callosal thickness in schizophrenia is gender related, a factor that is not considered by postmortem studies. The implications of increased callosal dimensions in female schizophrenics are discussed.
Details
- Title: Subtitle
- A controlled magnetic resonance imaging study of corpus callosum thickness in schizophrenia
- Creators
- Henry A Nasrallah - From the Department of Psychiatry, Ohio State University, Columbus, OH USANancy C Andreasen - the Department of Psychiatry University of Iowa, Iowa City, IA USAJeffrey A Coffman - From the Department of Psychiatry, Ohio State University, Columbus, OH USAStephen C Olson - From the Department of Psychiatry, Ohio State University, Columbus, OH USAVal D Dunn - the Department of Radiology, University of Iowa, Iowa City, IA USAJames C Ehrhardt - the Department of Radiology, University of Iowa, Iowa City, IA USASuzanne M Chapman - the Department of Psychiatry University of Iowa, Iowa City, IA USA
- Resource Type
- Journal article
- Publication Details
- Biological psychiatry (1969), Vol.21(3), pp.274-282
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0006-3223(86)90048-X
- PMID
- 3947709
- ISSN
- 0006-3223
- eISSN
- 1873-2402
- Language
- English
- Date published
- 1986
- Academic Unit
- Radiology; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984004091502771
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