A controlled quantitative MRI volumetric investigation of hippocampal contributions to immediate and delayed memory performance

H Randall Griffith; Robert W Pyzalski; Daniel O'Leary; Vincent Magnotta; Brian Bell; Christian Dow; Bruce Hermann; Michael Seidenberg

doi:10.1076/jcen.25.8.1117.16731

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A controlled quantitative MRI volumetric investigation of hippocampal contributions to immediate and delayed memory performance

Journal article

Peer reviewed

A controlled quantitative MRI volumetric investigation of hippocampal contributions to immediate and delayed memory performance

H Randall Griffith, Robert W Pyzalski, Daniel O'Leary, Vincent Magnotta, Brian Bell, Christian Dow, Bruce Hermann and Michael Seidenberg

Journal of clinical and experimental neuropsychology, Vol.25(8), pp.1117-1127

12/2003

DOI: 10.1076/jcen.25.8.1117.16731

PMID: 14566585

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Abstract

MRI volumetric TLE studies show inconsistent evidence of hippocampal involvement in memory. Prior studies have not dissociated hippocampal and temporal lobe contributions to memory. We measured hippocampal and temporal lobe volumes and immediate/delayed memory performances in 64 TLE patients. Regression was used to dissociate hippocampal from temporal lobe contributions to memory. Results revealed reliable evidence for dominant hippocampal involvement in delayed verbal recall across three separate measures and less consistent evidence for nondominant hippocampal involvement. The findings point to a consistent relationship of dominant hippocampal volumes to delayed verbal recall but no involvement of the temporal lobe or nondominant hippocampus in memory.

Humans

Middle Aged

Magnetic Resonance Imaging - methods

Epilepsy, Temporal Lobe - physiopathology

Male

Functional Laterality

Case-Control Studies

Neuropsychological Tests

Image Processing, Computer-Assisted

Adolescent

Brain Mapping

Adult

Female

Hippocampus - physiopathology

Memory - physiology

Details

Title: Subtitle: A controlled quantitative MRI volumetric investigation of hippocampal contributions to immediate and delayed memory performance
Creators: H Randall Griffith - Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35233-6890, USA. thalamus@uab.edu
Robert W Pyzalski
Daniel O'Leary
Vincent Magnotta
Brian Bell
Christian Dow
Bruce Hermann
Michael Seidenberg
Resource Type: Journal article
Publication Details: Journal of clinical and experimental neuropsychology, Vol.25(8), pp.1117-1127
DOI: 10.1076/jcen.25.8.1117.16731
PMID: 14566585
NLM abbreviation: J Clin Exp Neuropsychol
ISSN: 1380-3395
eISSN: 1744-411X
Publisher: Taylor & Francis Group; England
Grant note: NS-37738 / NINDS NIH HHS M01 RR03186 / NCRR NIH HHS
Language: English
Date published: 12/2003
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003957802771

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